加纳恶性疟原虫对氯喹和甲氟喹敏感性的体外评估。
In vitro assessment of sensitivity of Plasmodium falciparum to chloroquine and mefloquine in Ghana.
作者信息
Hogerzeil H V, Hogewoning A A, van Doorn J W, Wernsdorfer W H, van der Kaay H J
出版信息
Trans R Soc Trop Med Hyg. 1985;79(6):808-11. doi: 10.1016/0035-9203(85)90126-9.
An in vitro study of sensitivity of Plasmodium falciparum to chloroquine and mefloquine in Ghana is described. Results of 60 short-term cultures from 36 patients are evaluated. No sign of chloroquine resistance was found as all microtests showed complete inhibition of maturation at a level of 0.8 X 10(-6) M. For mefloquine schizont maturation was seen at higher levels of the drug. However, the estimated EC99, with 2.2830 X 10(-6) M is probably within the range of sensitivity.
本文描述了在加纳进行的恶性疟原虫对氯喹和甲氟喹敏感性的体外研究。评估了来自36名患者的60份短期培养物的结果。未发现氯喹耐药迹象，因为所有微量试验均显示在0.8×10⁻⁶M水平时完全抑制成熟。对于甲氟喹，在较高药物水平时可见裂殖体成熟。然而，估计的EC99为2.2830×10⁻⁶M，可能在敏感范围内。
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