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小儿代谢和减重手术的麻醉考虑因素。

Anesthesia considerations for pediatric metabolic and bariatric surgery.

机构信息

Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, and The Ohio State University, College of Medicine, Columbus, USA.

Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA.

出版信息

Surg Obes Relat Dis. 2024 Dec;20(12):1322-1328. doi: 10.1016/j.soard.2024.07.004. Epub 2024 Jul 11.

Abstract

Childhood obesity is a rapidly growing global health issue, linked to significant lifelong morbidity and mortality. Its impact on various organ systems increases perioperative complications. Obesity treatment in children and adolescents involves lifestyle, dietary, and behavioral modifications, as well as pharmacologic interventions that targets hormonal, metabolic, and neurochemical abnormalities. Metabolic and bariatric surgery, proven safe and effective for adults with severe obesity (class 2 or higher), is now being recommended for adolescents. Key anesthetic considerations for these surgeries include preoperative optimization, advanced airway management, targeted ventilation strategies, and opioid-sparing analgesic regimens. Comprehensive presurgical evaluations must address co-morbid conditions such as hypertension, obstructive sleep apnea, asthma, and impaired glycemic control. Preoperative management should also consider the effects of antiobesity medications on gastric emptying and hemodynamic stability. Ventilation strategies should prevent atelectasis while avoiding barotrauma, and drug dosages must be adjusted for altered pharmacokinetics due to increased adipose tissue. Employing enhanced recovery after surgery protocols may reduce perioperative complications, shorten postsurgical stays, and improve outcomes.

摘要

儿童肥胖是一个迅速增长的全球性健康问题,与显著的终身发病率和死亡率相关。它对各种器官系统的影响增加了围手术期并发症。儿童和青少年肥胖的治疗包括生活方式、饮食和行为改变,以及针对激素、代谢和神经化学异常的药物干预。代谢和减重手术已被证明对严重肥胖(2 级或更高)的成年人安全有效,现在也被推荐用于青少年。这些手术的关键麻醉考虑因素包括术前优化、先进的气道管理、靶向通气策略和阿片类药物节约性镇痛方案。综合术前评估必须解决合并症,如高血压、阻塞性睡眠呼吸暂停、哮喘和血糖控制受损。术前管理还应考虑抗肥胖药物对胃排空和血流动力学稳定性的影响。通气策略应防止肺不张,同时避免气压伤,并且必须根据增加的脂肪组织调整药物剂量以适应改变的药代动力学。采用手术后恢复增强方案可能会减少围手术期并发症,缩短术后住院时间并改善结果。

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