人脂肪间充质干细胞外泌体（hADSC-Exos）与抗氧化剂的协同递送对紫外线B（UVB）诱导的皮肤光老化具有抑制作用。

Fu Yu, Xie Jun-Ling, Zhang Wan-Ting, Zhang Xing-Liao, Zhang Xin-Min, Xu Meng-Meng, Han Yao-Ting, Liu Rong-Qi, Xie Guang-Ming, Zhang Jing, Zhang Jun

Research Center for Translational Medicine at East Hospital, School of Medicine, Tongji University, Shanghai, 200010, China.

Research Center for Translational Medicine at East Hospital, School of Life Science and Technology, Tongji University, Shangha, 200010, China.

Heliyon. 2024 Jul 9;10(15):e34321. doi: 10.1016/j.heliyon.2024.e34321. eCollection 2024 Aug 15.

Ultraviolet B (UVB) light exposure accelerates skin photoaging. Human adipose-derived stem cell exosomes (hADSC-Exos) and some antioxidants may have anti-photoaging effects. However, it is unknown whether the combination of hADSC-Exos and antioxidants plays a synergistic role in anti-photoaging. In cellular and 3D skin models, we showed that vitamin E (VE) and hADSC-Exos were optimal anti-photoaging combinations. In vivo, VE and hADSC-Exos increased skin tightening and elasticity in UVB-induced photoaging mice Combined treatment with VE and hADSC-Exos inhibited SIRT1/NF-κB pathway. These findings contribute to the understanding of hADSC-Exos in conjunction with other antioxidants, thereby providing valuable insights for the future pharmaceutical and cosmetic industries.

紫外线B（UVB）照射会加速皮肤光老化。人脂肪来源干细胞外泌体（hADSC-Exos）和一些抗氧化剂可能具有抗光老化作用。然而，hADSC-Exos与抗氧化剂的组合是否在抗光老化中发挥协同作用尚不清楚。在细胞和3D皮肤模型中，我们发现维生素E（VE）和hADSC-Exos是最佳的抗光老化组合。在体内，VE和hADSC-Exos可增加UVB诱导的光老化小鼠的皮肤紧致度和弹性。VE和hADSC-Exos联合治疗可抑制SIRT1/NF-κB通路。这些发现有助于理解hADSC-Exos与其他抗氧化剂的联合作用，从而为未来的制药和化妆品行业提供有价值的见解。