Leadership Sinai Centre for Diabetes, Sinai Health, Toronto, ON, Canada.
Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Diabetologia. 2024 Oct;67(10):2045-2058. doi: 10.1007/s00125-024-06229-x. Epub 2024 Aug 15.
Challenges and fears related to managing glucose levels around planned and spontaneous exercise affect outcomes and quality of life in people living with type 1 diabetes. Advances in technology, including continuous glucose monitoring, open-loop insulin pump therapy and hybrid closed-loop (HCL) systems for exercise management in type 1 diabetes, address some of these challenges. In this review, three research or clinical experts, each living with type 1 diabetes, leverage published literature and clinical and personal experiences to translate research findings into simplified, patient-centred strategies. With an understanding of limitations in insulin pharmacokinetics, variable intra-individual responses to aerobic and anaerobic exercise, and the features of the technologies, six steps are proposed to guide clinicians in efficiently communicating simplified actions more effectively to individuals with type 1 diabetes. Fundamentally, the six steps centre on two aspects. First, regardless of insulin therapy type, and especially needed for spontaneous exercise, we provide an estimate of glucose disposal into active muscle meant to be consumed as extra carbohydrates for exercise ('ExCarbs'; a common example is 0.5 g/kg body mass per hour for adults and 1.0 g/kg body mass per hour for youth). Second, for planned exercise using open-loop pump therapy or HCL systems, we additionally recommend pre-emptive basal insulin reduction or using HCL exercise modes initiated 90 min (1-2 h) before the start of exercise until the end of exercise. Modifications for aerobic- and anaerobic-type exercise are discussed. The burden of pre-emptive basal insulin reductions and consumption of ExCarbs are the limitations of HCL systems, which may be overcome by future innovations but are unquestionably required for currently available systems.
在计划和自发性运动期间管理血糖水平相关的挑战和恐惧会影响 1 型糖尿病患者的结局和生活质量。技术的进步,包括连续血糖监测、闭环胰岛素泵治疗和 1 型糖尿病运动管理的混合闭环 (HCL) 系统,解决了其中的一些挑战。在这篇综述中,三位患有 1 型糖尿病的研究或临床专家利用已发表的文献和临床及个人经验,将研究结果转化为简化的以患者为中心的策略。了解胰岛素药代动力学的局限性、个体对有氧运动和无氧运动的不同反应以及技术的特点,提出了六个步骤,以指导临床医生更有效地向 1 型糖尿病患者传达简化的行动。从根本上说,这六个步骤主要集中在两个方面。首先,无论胰岛素治疗类型如何,尤其是对于自发性运动,我们需要估算进入活跃肌肉的葡萄糖消耗,以便作为运动时的额外碳水化合物(“ExCarbs”;对于成年人来说,常见的例子是每小时 0.5 g/kg 体重,对于青少年来说是每小时 1.0 g/kg 体重)。其次,对于使用闭环泵治疗或 HCL 系统的计划性运动,我们还建议在运动开始前 90 分钟(1-2 小时)预先减少基础胰岛素或使用 HCL 运动模式,直到运动结束。讨论了有氧运动和无氧运动的修改。HCL 系统的局限性在于预先减少基础胰岛素和消耗 ExCarbs 的负担,这些局限性可能会被未来的创新所克服,但目前可用的系统无疑需要这些。