硫酸铜/ -（9 - 咔唑 - 9 - 基）吡啶甲酰胺催化（杂）芳基氯与酚类在水相中的碳 - 氧偶联反应
CuSO/-(9-carbazol-9-yl)picolinamide-Catalyzed C-O Coupling of (Hetero)Aryl Chlorides with Phenols on Water.
作者信息
Hong Peng, Zhu Xinhai, Chen Fu, Huang Manna, Wan Yiqian
机构信息
School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, P. R. China.
Guangdong Engineering Technology Research Center for Platform Chemicals from Marine Biomass and Their Functionalization, Sun Yat-sen University, Zhuhai 519082, P. R. China.
出版信息
Org Lett. 2024 Aug 30;26(34):7202-7206. doi: 10.1021/acs.orglett.4c02620. Epub 2024 Aug 21.
A Cu-catalyzed C-O coupling of (hetero)aryl chlorides with phenols at 120 °C on water was developed with a designed ligand, -(9-carbazol-9-yl)picolinamide (). This method features a good substrate scope (both electron-donating and electron-withdrawing), low catalyst/ligand loadings (down to 1 mol %), and excellent scalability and practicability.
利用设计的配体 -（9 - 咔唑 - 9 - 基）吡啶甲酰胺，在120℃的水相中实现了铜催化的（杂）芳基氯化物与酚类的C - O偶联反应。该方法具有良好的底物范围（包括供电子和吸电子底物）、低催化剂/配体负载量（低至1 mol%）以及出色的可扩展性和实用性。
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