Department of Dermatology, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Cell Prolif. 2024 Nov;57(11):e13684. doi: 10.1111/cpr.13684. Epub 2024 Aug 26.
Interleukin-18 (IL-18) is a vital pro-inflammatory cytokine crucial for immune regulation. Despite its significance, bibliometric analysis in this field is lacking. This study aims to quantitatively and qualitatively assess IL-18 research to construct its intellectual base and predict future hotspots. We conducted a thorough search on the Web of Science Core Collection for relevant publications between 1 January 2012 and 31 December 2022. English-language articles and reviews were included. Visual analysis was performed using various tools including VOSviewer, Citespace, and Microsoft Excel. Our analysis covers interleukin-18 (IL-18) literature from 2012 to 2022, exploring research trends comprehensively. Key institutions like Yale University and Shanghai Jiao Tong University emerged as significant contributors. Prolific authors such as Kanneganti and Dinarello made notable contributions. Main focus areas included biology, medicine, and immunology. Co-citation analysis highlighted influential works like Jianjin Shi. Hotspot keyword frequency cluster analysis revealed emerging themes like pyroptosis and psoriasis. Gene co-occurrence clustering identified genes associated with immune regulation and inflammation. GO and KEGG pathway enrichment analysis provided insights into IL-18-related biological processes and pathways. Protein-protein interaction networks identified core proteins such as IL10 and TNF. Association disease analysis linked IL-18 to various inflammatory, autoimmune, and metabolic disorders. This bibliometric review offers insights into IL-18 research trends over the past decade, guiding future investigations and serving as a reference for researchers in this field.
白细胞介素-18 (IL-18) 是一种重要的促炎细胞因子，对免疫调节至关重要。尽管它很重要，但在该领域缺乏文献计量分析。本研究旨在定量和定性评估 IL-18 的研究，构建其知识基础，并预测未来的热点。我们在 Web of Science 核心合集上进行了全面搜索，以获取 2012 年 1 月 1 日至 2022 年 12 月 31 日期间的相关出版物。包括英文文章和评论。使用各种工具（包括 VOSviewer、Citespace 和 Microsoft Excel）进行可视化分析。我们的分析涵盖了 2012 年至 2022 年的白细胞介素-18 (IL-18) 文献，全面探讨了研究趋势。耶鲁大学和上海交通大学等重要机构是重要的贡献者。Kanneganti 和 Dinarello 等多产作者做出了重要贡献。主要关注领域包括生物学、医学和免疫学。共被引分析突出了像 Jianjin Shi 这样的有影响力的作品。热点关键词频率聚类分析揭示了细胞焦亡和银屑病等新兴主题。基因共表达聚类分析确定了与免疫调节和炎症相关的基因。GO 和 KEGG 途径富集分析提供了有关 IL-18 相关生物过程和途径的见解。蛋白质-蛋白质相互作用网络确定了核心蛋白，如 IL10 和 TNF。关联疾病分析将 IL-18 与各种炎症、自身免疫和代谢疾病联系起来。这项文献计量学综述提供了过去十年中白细胞介素-18 研究趋势的见解，指导未来的研究，并为该领域的研究人员提供参考。
