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热塑面罩在头颈部放疗中引起的剂量突增效应。

Bolus Effect Caused by Use of Thermoplastic Masks in Head and Neck Radiotherapy Treatments.

机构信息

Applied Nuclear Physics and Simulation Research Group, Pedagogical and Technological University of Colombia, Tunja 150003, Colombia.

Radiotherapy Department, Clínica de las Américas AUNA, Medellin 050032, Colombia.

出版信息

Int J Mol Sci. 2024 Aug 22;25(16):9133. doi: 10.3390/ijms25169133.

Abstract

This paper examines the dosimetric uncertainty arising from the use of thermoplastic masks in the treatment of head and neck cancer through radiotherapy. This study was conducted through Monte Carlo simulations using the Monte Carlo N-Particle eXtended (MCNPX code), and the theoretical results are compared with radiochromic films. Using material characterization techniques, the compounds of the thermoplastic mask were identified, confirming that most of the material corresponds to the polymer CHO. The theoretical results show increases ranging from 42% to 57.4% in the surface absorbed dose for 6 and 15 MV photon beams, respectively, compared to the absorbed dose without the mask. The experimental data corroborate these findings, showing dose increases ranging from 18.4% to 52.1% compared to the expected surface absorbed dose without the mask. These results highlight the need to consider the bolus effect induced by thermoplastic masks during the precise and safe planning and application of radiotherapy treatment in order to ensure its therapeutic efficacy and minimize the associated risks to patients.

摘要

本文通过放射治疗研究了热塑面具在头颈部癌症治疗中产生的剂量不确定性。本研究通过使用蒙特卡罗 N-粒子扩展(MCNPX 代码)的蒙特卡罗模拟进行,理论结果与光致变色胶片进行了比较。通过材料特性分析技术,鉴定了热塑面具的化合物,证实大部分材料对应于聚合物 CHO。理论结果表明,与没有面具的情况下相比,6 和 15 MV 光子束的表面吸收剂量分别增加了 42%至 57.4%。实验数据证实了这些发现,与没有面具的情况下的预期表面吸收剂量相比,剂量增加了 18.4%至 52.1%。这些结果强调了在精确和安全地规划和应用放射治疗时需要考虑热塑面具引起的增感效应,以确保其治疗效果并将相关风险降到最低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f20e/11354977/9a7576fd2658/ijms-25-09133-g001.jpg

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