Zeng Meng-Ting, Huang Li-Yue, Zheng Xiao-Hui, Fu Yan-Qi, Weng Ching-Feng
Functional Physiology Section, Department of Basic Medical Science, Xiamen Medical College, Xiamen 361023, China.
Institute of Respiratory Disease, Department of Basic Medical Science, Xiamen Medical College, Xiamen 361023, China.
Pharmaceuticals (Basel). 2024 Jul 29;17(8):1003. doi: 10.3390/ph17081003.
Sudden cardiac death (SCD) is responsible for a high percentage of cardiovascular fatalities, with ventricular arrhythmias being the most common cause. Despite numerous clinically available antiarrhythmic drugs (AADs), AADs retain some undesirable arrhythmic effects, and their inappropriate use can lead to severe adverse reactions. The exploration of new therapeutic options against arrhythmias with fewer unreceptive effects is of utmost importance. The ethanolic extracts of seven Cupressaceae species, namely, , (L.) Ant., (L.) Ant. cv. Kaizuca, (L.) Franco, L., , and 'Pyramidalis' were investigated for their pharmacological effects on barium chloride (BaCl)-induced arrhythmia using normal II lead electrocardiogram (ECG) measurements in a mouse model. According to the ECG profiles, pretreatment with , , and extracts provoked dose-dependent protection against BaCl-induced arrhythmia, while pretreatment with the other four species and amiodarone did not exert cardioprotective effects. The treatment effects were confirmed using a rat model. The therapeutic effects of , , and extracts on the M2 and M3 receptors but not the M1 receptor were mediated by the inhibition of the M2 receptor blocker (methoctramine tetrahydrochloride), M3 antagonist (4-DAMP), or M1 receptor blocker (pirenzepine dihydrochloride). This first-line evidence illustrates that certain Cupressaceae species possess active antiarrhythmic components. The first line of key findings revealed that active components of certain Cupressaceae species have cardioprotective effects, suggesting that these innovative phytochemicals have promising potential for preventing the occurrence of cardiac arrhythmia and reducing sudden cardiac death.
心源性猝死（SCD）在心血管死亡中占比很高，室性心律失常是最常见的原因。尽管临床上有多种抗心律失常药物（AADs）可用，但AADs仍有一些不良的心律失常作用，其不当使用会导致严重不良反应。探索具有较少不良反应的抗心律失常新治疗选择至关重要。研究了柏科七种植物的乙醇提取物，即[具体植物名称1]、[具体植物名称2]（L.）Ant.、[具体植物名称3]（L.）Ant. cv. Kaizuca、[具体植物名称4]（L.）Franco、[具体植物名称5] L.、[具体植物名称6]和[具体植物名称7] 'Pyramidalis'，通过在小鼠模型中使用正常II导联心电图（ECG）测量，研究它们对氯化钡（BaCl）诱导的心律失常的药理作用。根据ECG图谱，用[具体植物名称1]、[具体植物名称2]和[具体植物名称3]提取物预处理可对BaCl诱导的心律失常产生剂量依赖性保护作用，而用其他四种植物提取物和胺碘酮预处理则未发挥心脏保护作用。使用大鼠模型证实了治疗效果。[具体植物名称1]、[具体植物名称2]和[具体植物名称3]提取物对M2和M3受体而非M1受体的治疗作用是通过抑制M2受体阻滞剂（四盐酸美托咪啶）、M3拮抗剂（4 - DAMP）或M1受体阻滞剂（二盐酸哌仑西平）介导的。这一初步证据表明某些柏科植物具有活性抗心律失常成分。首要关键发现表明，某些柏科植物的活性成分具有心脏保护作用，这表明这些创新的植物化学物质在预防心律失常发生和降低心源性猝死方面具有广阔的潜力。
