CD33 变体与高血压协同作用与痴呆症老年人的脑和认知老化的关系：一项基于人群的研究。
Synergistic associations of CD33 variants and hypertension with brain and cognitive aging among dementia-free older adults: A population-based study.
机构信息
Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, P.R. China.
Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education, Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China.
出版信息
Alzheimers Dement. 2024 Oct;20(10):7193-7204. doi: 10.1002/alz.14209. Epub 2024 Aug 30.
INTRODUCTION
CD33 rs3865444 and hypertension (HTN) are related to cognitive impairment, individually. However, little is known about their combined effects on cognitive function in older adults.
METHODS
This population-based study included 4368 dementia-free participants (age ≥65 years) in the Multimodal Interventions to Delay Dementia and Disability in Rural China (MIND-China), with data available in 1044 persons for gray matter volume and 85 persons for cerebral blood flow (CBF). We used general linear regression and mediation models to examine the associations of rs3865444 and HTN with cognition, brain atrophy, and CBF.
RESULTS
Among rs3865444 CC carriers, HTN and late-life HTN were significantly associated with impaired cognition. Midlife and late-life HTN were correlated with brain atrophy. CD33 rs3865444 CC moderated the mediation effect of gray matter volume on the association between HTN and global cognition. HTN was correlated with low CBF in rs3865444 CC carriers.
DISCUSSION
There are synergistic associations of CD33 rs3865444 and HTN with brain and cognitive aging in dementia-free older adults.
简介
CD33 rs3865444 和高血压（HTN）单独与认知障碍有关。然而，关于它们对老年人认知功能的综合影响知之甚少。
方法
这项基于人群的研究纳入了来自中国农村多模态干预延缓痴呆和残疾研究（MIND-China）的 4368 名无痴呆症的参与者（年龄≥65 岁），其中 1044 人的大脑灰质体积和 85 人的脑血流（CBF）数据可用。我们使用一般线性回归和中介模型来研究 rs3865444 和 HTN 与认知、脑萎缩和 CBF 的关系。
结果
在 rs3865444 CC 携带者中，HTN 和晚年 HTN 与认知障碍显著相关。中年和晚年 HTN 与脑萎缩相关。CD33 rs3865444 CC 调节了灰质体积与 HTN 和整体认知之间关联的中介效应。HTN 与 rs3865444 CC 携带者的低 CBF 相关。
讨论
在无痴呆症的老年人群中，CD33 rs3865444 和 HTN 与大脑和认知衰老之间存在协同关联。
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