Rajagopal Divya, Al Rashid Sulthan, Prasad Monisha, Fareed Mohammad
Department of Pharmacology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, IND.
Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, IND.
Cureus. 2024 Jul 31;16(7):e65910. doi: 10.7759/cureus.65910. eCollection 2024 Jul.
Glucagon-like peptide-1 (GLP-1) receptor agonists have drawn a lot of interest lately for their therapeutic advantages over controlling blood sugar levels in the management of type 2 diabetes mellitus (T2DM). This review aims to provide an overview of the research that has been done on the neuroprotective, renoprotective, and cardioprotective effects of GLP-1 receptor agonists. Studies suggest that these medicines could provide protective benefits beyond glucose regulation, possibly reducing the risks of cardiovascular and renal issues; mechanisms underlying these advantages are still not fully understood. The review emphasizes how crucial it is to conduct more studies to determine the clinical significance and underlying mechanisms of these protective benefits. Improved knowledge of GLP-1 receptor agonists may result in T2DM treatment plans that improve neurological, cardiovascular, and renal function in addition to blood sugar control. Therefore, further research is necessary to fully understand the potential of GLP-1 receptor agonists in providing comprehensive protection against complications related to T2DM.
胰高血糖素样肽-1(GLP-1)受体激动剂因其在2型糖尿病(T2DM)管理中控制血糖水平方面的治疗优势,近来备受关注。本综述旨在概述有关GLP-1受体激动剂的神经保护、肾保护和心脏保护作用的研究。研究表明,这些药物可能除了调节血糖外还具有保护作用,有可能降低心血管和肾脏问题的风险;这些优势背后的机制仍未完全了解。该综述强调进行更多研究以确定这些保护作用的临床意义和潜在机制的重要性。对GLP-1受体激动剂的深入了解可能会带来T2DM治疗方案,除了控制血糖外,还能改善神经、心血管和肾脏功能。因此,有必要进一步研究以充分了解GLP-1受体激动剂在全面预防T2DM相关并发症方面的潜力。