使用眼动和手动反应范式评估近视野青光眼患者的视觉拥挤。

Assessing Visual Crowding in Participants With Preperimetric Glaucoma Using Eye Movement and Manual Response Paradigms.

机构信息

Laboratory for Experimental Ophthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Section for Clinical and Experimental Sensory Physiology, Ophthalmic Department, Otto-von-Guericke University, Magdeburg, Germany.

出版信息

Transl Vis Sci Technol. 2024 Sep 3;13(9):8. doi: 10.1167/tvst.13.9.8.

PURPOSE

Crowding is the inability to distinguish objects in the periphery in the presence of clutter. Previous studies showed that crowding is elevated in patients with glaucoma. This could serve as an indicator of the functional visual performance of patients with glaucoma but at present appears too time-consuming and attentionally demanding. We examined visual crowding in individuals with preperimetric glaucoma to compare the potential effectiveness of eye movement-based and manual response paradigms.

METHODS

We assessed crowding magnitude in 10 participants with preperimetric glaucoma and 10 age-matched controls. Crowding magnitudes were assessed using four different paradigms: a conventional two-alternative forced choice (2AFC) manual, a 2AFC and a six-alternative forced choice (6AFC) eye movement, and a serial search paradigm. All paradigms measured crowding magnitude by comparing participants' orientation discrimination thresholds in isolated and flanked stimulus conditions. Moreover, assessment times and participant preferences were compared across paradigms.

RESULTS

Patients with preperimetric glaucoma exhibited elevated crowding, which was most evident in the manual-response paradigm. The serial search paradigm emerged as the fastest method for assessing thresholds, yet it could not effectively distinguish between glaucoma and control groups. The 6AFC paradigm proved challenging for both groups.

CONCLUSIONS

We conclude that patients with preperimetric glaucoma demonstrate heightened binocular visual crowding. This is most effectively demonstrated via the 2AFC manual response paradigm. The additional attentional demand in eye movement paradigms rendered them less effective in the elderly population of the present study.

TRANSLATIONAL RELEVANCE

Our findings underscore both the value and the complexity of efficiently evaluating crowding in elderly participants, including those with preperimetric glaucoma.

目的

拥挤是指在存在杂乱的情况下无法分辨周边物体的能力。先前的研究表明，青光眼患者的拥挤程度升高。这可以作为青光眼患者功能视觉表现的指标，但目前似乎过于耗时且需要注意力。我们检查了有前期青光眼的个体的视觉拥挤情况，以比较基于眼动和手动反应范式的潜在有效性。

方法

我们评估了 10 名前期青光眼患者和 10 名年龄匹配的对照者的拥挤程度。使用四种不同的范式评估了拥挤程度：传统的二选一强制选择（2AFC）手动、2AFC 和六选一强制选择（6AFC）眼动以及序列搜索范式。所有范式都通过比较参与者在孤立和侧翼刺激条件下的方向辨别阈值来衡量拥挤程度。此外，还比较了不同范式之间的评估时间和参与者偏好。