脊髓损伤后神经血管单元中的铁死亡。
Ferroptosis in the neurovascular unit after spinal cord injury.
机构信息
School of Rehabilitation, Capital Medical University, Beijing, China.
School of Rehabilitation, Capital Medical University, Beijing, China; Department of Spine and Spinal Cord Surgery, Beijing Boai Hospital, China Rehabilitation Research Center, Beijing, China; Department of Orthopedics, Capital Medical University, Beijing, China.
出版信息
Exp Neurol. 2024 Nov;381:114943. doi: 10.1016/j.expneurol.2024.114943. Epub 2024 Sep 4.
The mechanisms of secondary injury following spinal cord injury are complicated. The role of ferroptosis, which is a newly discovered form of regulated cell death in the neurovascular unit(NVU), is increasingly important. Ferroptosis inhibitors have been shown to improve neurovascular homeostasis and attenuate secondary spinal cord injury(SCI). This review focuses on the mechanisms of ferroptosis in NVU cells and NVU-targeted therapeutic strategies according to the stages of SCI, and analyzes possible future research directions.
脊髓损伤后继发性损伤的机制很复杂。铁死亡是神经血管单元（NVU）中一种新发现的细胞死亡形式，其作用越来越重要。铁死亡抑制剂已被证明可以改善神经血管内环境平衡并减轻继发性脊髓损伤（SCI）。本文根据 SCI 阶段，重点综述了 NVU 细胞中铁死亡的机制及针对 NVU 的治疗策略，并分析了可能的未来研究方向。
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