尼日利亚北部扎里亚分离的淋病奈瑟菌菌株的敏感性模式及β-内酰胺酶筛查
Sensitivity pattern and beta-lactamase screening of Neisseria gonorrhoeae strains isolated in Zaria, Northern Nigeria.
作者信息
Joshi R M, Lawande R V
出版信息
Trop Geogr Med. 1985 Mar;37(1):74-6.
One hundred and sixty strains of N. gonorrhoeae were studied for their in-vitro sensitivity to six different antimicrobial agents and tested for beta-lactamase production in Zaria, Northern Nigeria. While 82% of strains were sensitive to erythromycin, 70% to tetracycline and 61% to chloramphenicol, only 35%, 33% and 24% were sensitive to ampicillin, penicillin and streptomycin respectively. Penicillin is no more the drug of choice in the treatment of gonorrhoea in this environment since two thirds of strains are either partially resistant or completely resistant to penicillin and 44% of strains are beta-lactamase producers. Erythromycin/tetracycline are recommended as the drugs of choice.
在尼日利亚北部的扎里亚，对160株淋病奈瑟菌进行了研究，检测它们对六种不同抗菌剂的体外敏感性，并测试了β-内酰胺酶的产生情况。82%的菌株对红霉素敏感，70%对四环素敏感，61%对氯霉素敏感，而对氨苄青霉素、青霉素和链霉素敏感的菌株分别仅为35%、33%和24%。在这种环境下，青霉素不再是淋病治疗的首选药物，因为三分之二的菌株对青霉素部分耐药或完全耐药，且44%的菌株产生β-内酰胺酶。推荐将红霉素/四环素作为首选药物。
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