Trevizan-Baú Pedro, Hayes John A, Bolser Donald C, Reznikov Leah R
Department of Physiological Sciences, University of Florida, Gainesville, FL, United States.
Front Physiol. 2024 Aug 28;15:1424889. doi: 10.3389/fphys.2024.1424889. eCollection 2024.
The brainstem has long been recognized as the major respiratory control center, but it has become increasingly appreciated that areas upstream of the brainstem modulate respiration and airway defensive behaviors. This review aims to define the role of the amygdala, a key temporal brain region essential for limbic function, in respiration and airway defenses. We summarize literature describing roles for the amygdala in control of respiration, swallow, cough, airway smooth muscle contraction, and mucus secretion. We emphasize the need to understand how the amygdala regulates these functions both at a local scale and network scale and identify knowledge gaps for current and future investigations. Lastly, we highlight literature suggesting that amygdala dysfunction may contribute to respiratory dysfunction.
长期以来，脑干一直被认为是主要的呼吸控制中心，但人们越来越认识到，脑干上游区域会调节呼吸和气道防御行为。本综述旨在明确杏仁核（一个对边缘系统功能至关重要的关键颞叶脑区）在呼吸和气道防御中的作用。我们总结了描述杏仁核在呼吸控制、吞咽、咳嗽、气道平滑肌收缩和黏液分泌中作用的文献。我们强调需要了解杏仁核如何在局部和网络层面调节这些功能，并确定当前和未来研究中的知识空白。最后，我们着重介绍了表明杏仁核功能障碍可能导致呼吸功能障碍的文献。
