Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Cell Genom. 2024 Sep 11;4(9):100652. doi: 10.1016/j.xgen.2024.100652.
Missing regulatory effects of asthma genetic risks might be hidden within specific cell states. In this issue of Cell Genomics, Djeddi et al. uncover how airway epithelial cells, when activated by rhinovirus, influence genetic susceptibility to childhood-onset asthma, and this preview emphasizes the need to address these missing regulatory effects across diverse cell states.
哮喘遗传风险的缺失调控效应可能隐藏在特定的细胞状态中。在本期《细胞基因组学》中，Djeddi 等人揭示了呼吸道上皮细胞在被鼻病毒激活时如何影响儿童期发病哮喘的遗传易感性，这篇预览强调了需要在不同的细胞状态下解决这些缺失的调控效应。
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