1990年至2021年10至24岁青少年和青年寻常痤疮的全球、区域和国家负担：一项趋势分析

Global, regional and national burdens of acne vulgaris in adolescents and young adults aged 10-24 years from 1990 to 2021: a trend analysis.

作者信息

Zhu Zhou, Zhong Xiaoying, Luo Zhongyu, Liu Mingjuan, Zhang Hanlin, Zheng Heyi, Li Jun

机构信息

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

出版信息

Br J Dermatol. 2025 Jan 24;192(2):228-237. doi: 10.1093/bjd/ljae352.

DOI:10.1093/bjd/ljae352

PMID:39271178

Abstract

BACKGROUND

Acne vulgaris is a common skin condition affecting adolescents and young adults worldwide, yet data on the burden and trends of this disease remain limited. We aimed to investigate trends in the burden of acne vulgaris among adolescents and young adults aged 10-24 years at global, regional and national levels.

METHODS

We retrieved data from the Global Burden of Disease Study 2021 for individuals aged 10-24 years in 204 countries and territories from 1990 to 2021. We analysed the numbers, age-standardized rates and average annual percentage changes (AAPCs) of the prevalence, incidence and disability-adjusted life years (DALYs) for acne vulgaris at the global, regional and national levels. Additionally, we examined these global trends by age, sex and Sociodemographic Index (SDI).

RESULTS

Globally, the age-standardized prevalence rate of acne vulgaris among adolescents and young adults increased from 8563.4 per 100 000 population [95% uncertainty interval (UI) 7343.5-9920.1] in 1990 to 9790.5 (95% UI 8420.9-11 287.2) per 100 000 population in 2021, with an AAPC of 0.43 [95% confidence interval (CI) 0.41-0.46]. The age-standardized incidence rate and age-standardized DALY rate also showed a similar upward trend. Regionally, Western Europe had the highest age-standardized prevalence, incidence and DALY rates, while North Africa and the Middle East had the largest increase in these rates. By SDI quintile, the high SDI region had the highest age-standardized prevalence, incidence and DALY rates from 1990 to 2021, whereas the low-middle SDI region had the lowest burden of acne vulgaris but experienced the most significant increase in these rates. Globally, the age-standardized prevalence rate of acne vulgaris in 2021 was approximately 25% higher in young women than in young men (10 911.8 per 100 000 population vs. 8727.8 per 100 000 population). Among all age groups, adolescents aged 15-19 years had the highest age-specific prevalence rate, while adolescents aged 10-14 years experienced the largest increase from 1990 to 2021 (AAPC 0.50, 95% CI 0.48-0.52).

CONCLUSIONS

The burden of acne vulgaris among adolescents and young adults has continued to increase in nearly all countries since the 1990s. Managing this condition remains a significant challenge, necessitating more effective and targeted interventions to control the acne burden.

摘要

背景

寻常痤疮是一种常见的皮肤疾病，影响着全球的青少年和青年，但关于该疾病负担及趋势的数据仍然有限。我们旨在调查全球、区域和国家层面10至24岁青少年和青年中寻常痤疮的负担趋势。

方法

我们从《2021年全球疾病负担研究》中检索了1990年至2021年204个国家和地区10至24岁个体的数据。我们分析了全球、区域和国家层面寻常痤疮患病率、发病率及伤残调整生命年（DALYs）的数量、年龄标准化率和年均百分比变化（AAPCs）。此外，我们按年龄、性别和社会人口指数（SDI）研究了这些全球趋势。

结果

在全球范围内，青少年和青年中寻常痤疮的年龄标准化患病率从1990年的每10万人8563.4例[95%不确定区间（UI）7343.5 - 9920.1]增至2021年的每10万人9790.5例（95% UI 8420.9 - 11287.2），年均百分比变化为0.43[95%置信区间（CI）0.41 - 0.46]。年龄标准化发病率和年龄标准化DALY率也呈现出类似的上升趋势。在区域层面，西欧的年龄标准化患病率、发病率和DALY率最高，而北非和中东这些比率的增幅最大。按SDI五分位数划分，高SDI地区在1990年至2021年期间年龄标准化患病率、发病率和DALY率最高，而低 - 中SDI地区寻常痤疮负担最低，但这些比率的增幅最为显著。在全球范围内，2021年年轻女性中寻常痤疮的年龄标准化患病率比年轻男性高约25%（每10万人10911.8例 vs. 每10万人8727.8例）。在所有年龄组中，15至19岁的青少年年龄特异性患病率最高，而10至14岁的青少年在1990年至2021年期间增幅最大（年均百分比变化0.50，95% CI 0.48 - 0.52）。