不同运动对多囊卵巢综合征妇女体重减轻和激素变化的影响：一项网络荟萃分析研究。
The effects of different exercises on weight loss and hormonal changes in women with polycystic ovarian syndrome: a network meta-analysis study.
机构信息
Department of Occupational Therapy, School of Rehabilitation Sciences, Semnan University of Medical Sciences, Semnan, Iran.
Neuromuscular Rehabilitation Research Center, Semnan University of Medical Sciences, Semnan, Iran.
出版信息
BMC Womens Health. 2024 Sep 13;24(1):512. doi: 10.1186/s12905-024-03297-4.
BACKGROUND
Polycystic ovarian syndrome (PCOS) is one of the most common endocrine illnesses. There is evidence that exercise training positively affects on improvement of the pathogenic factors in women with PCOS. On the other hand, some studies reported similar effects of aerobic and resistance exercises or no effect of exercises on the improvement of the pathogenic factors. The aim of the current study was to perform a network meta-analysis of RCTs to evaluate the efficacy of exercises on body mass index (BMI), hormone concentrations, and regular menstruation in women with PCOS.
METHODS
The search was performed from databases of PubMed, Scopus, and Web of Science with the keywords of exercise, resistance exercise, aerobic exercise, endurance exercise, yoga, polycystic ovary syndrome, randomized controlled trial based on the CONSORT, BMI, sex hormone and regular menstruation from inception until April 15, 2022. Bayesian random-effects network meta-analyses were performed to calculate mean difference and 95% credible intervals.
RESULTS
Out of 1140 studies, 19 were eligible for inclusion. The results showed that moderate-intensity aerobic exercise effectively reduces BMI compared to no intervention and Yoga. No other forms of exercise led to weight loss. Additionally, exercise had no impact on sex hormones and regular menstruation. It was concluded that moderate-intensity aerobic exercise is the most effective for reducing BMI in women with PCOS.
CONCLUSIONS
Due to the limitations regarding the small sample size and lack of subgroup and sensitivity analysis, the results of this study demonstrated that moderate-intensity, aerobic exercise is the most effective exercise for reducing BMI, while the other exercises were ineffective. Moderate-intensity aerobic exercise is suggested to decrease the BMI in women with PCOS.
SYSTEMATIC REVIEW REGISTRATION
This systematic review and network meta-analysis study was registered in PROSPERO (CRD42022324839).
背景
多囊卵巢综合征（PCOS）是最常见的内分泌疾病之一。有证据表明，运动训练对改善 PCOS 女性的致病因素有积极影响。另一方面，一些研究报告称，有氧运动和抗阻运动具有相似的效果，或者运动对改善致病因素没有效果。本研究的目的是进行一项 RCT 的网络荟萃分析，以评估运动对 PCOS 妇女体重指数（BMI）、激素浓度和规律月经的疗效。
方法
使用关键词“exercise（运动）”、“resistance exercise（抗阻运动）”、“aerobic exercise（有氧运动）”、“endurance exercise（耐力运动）”、“yoga（瑜伽）”、“polycystic ovary syndrome（多囊卵巢综合征）”、“randomized controlled trial（随机对照试验）”、“based on the CONSORT（符合 CONSORT 原则）”、“BMI（体重指数）”、“sex hormone（性激素）”和“regular menstruation（规律月经）”，从 PubMed、Scopus 和 Web of Science 数据库中进行搜索。基于 CONSORT 原则，检索时间从建库开始至 2022 年 4 月 15 日。采用贝叶斯随机效应网络荟萃分析计算均数差和 95%可信区间。
结果
从 1140 项研究中，有 19 项符合纳入标准。结果表明，与无干预和瑜伽相比，中等强度有氧运动能有效降低 BMI。其他形式的运动没有导致体重减轻。此外，运动对性激素和规律月经没有影响。研究得出结论，中等强度有氧运动是降低 PCOS 妇女 BMI 的最有效方法。
结论
由于样本量小、缺乏亚组和敏感性分析的限制，本研究结果表明，中等强度的有氧运动是降低 BMI 的最有效运动方式，而其他运动方式则无效。建议中等强度有氧运动用于降低 PCOS 妇女的 BMI。
系统评价注册
本系统评价和网络荟萃分析研究已在 PROSPERO（CRD42022324839）注册。
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