泛素结合酶E2 O（UBE2O）及其在人类白血病和实体瘤中的治疗潜力。
The Ubiquitin-Conjugating Enzyme E2 O (UBE2O) and Its Therapeutic Potential in Human Leukemias and Solid Tumors.
作者信息
Maffeo Beatrice, Cilloni Daniela
机构信息
Department of Clinical and Biological Sciences, University of Turin, 10043 Orbassano, Italy.
出版信息
Cancers (Basel). 2024 Sep 3;16(17):3064. doi: 10.3390/cancers16173064.
Protein degradation is a biological phenomenon essential for cellular homeostasis and survival. Selective protein degradation is performed by the ubiquitination system which selectively targets proteins that need to be eliminated and leads them to proteasome degradation. In this narrative review, we focus on the ubiquitin-conjugating enzyme E2 O (UBE2O) and highlight the role of UBE2O in many biological and physiological processes. We further discuss UBE2O's implications in various human diseases, particularly in leukemias and solid cancers. Ultimately, our review aims to highlight the potential role of UBE2O as a therapeutic target and offers new perspectives for developing targeted treatments for human cancers.
蛋白质降解是细胞内稳态和生存所必需的生物学现象。选择性蛋白质降解由泛素化系统执行，该系统选择性地靶向需要清除的蛋白质并将其引导至蛋白酶体降解。在这篇叙述性综述中，我们聚焦于泛素结合酶E2 O（UBE2O），并强调UBE2O在许多生物学和生理过程中的作用。我们进一步讨论了UBE2O在各种人类疾病中的影响，特别是在白血病和实体癌中的影响。最终，我们的综述旨在突出UBE2O作为治疗靶点的潜在作用，并为开发针对人类癌症的靶向治疗提供新的视角。
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