2 型糖尿病伴或不伴肾脏疾病患者血液、血清和血细胞中选定微量元素的评估。
The Evaluation of Selected Trace Elements in Blood, Serum and Blood Cells of Type 2 Diabetes Patients with and without Renal Disorder.
机构信息
Department of Clinical Pharmacology, Medical University of Lodz, 90-153 Lodz, Poland.
Students' Research Club, Department of Clinical Pharmacology, Medical University of Lodz, 90-153 Lodz, Poland.
出版信息
Nutrients. 2024 Sep 4;16(17):2989. doi: 10.3390/nu16172989.
BACKGROUND
An appropriate diet is the basis for the treatment of type 2 diabetes (T2DM). However, there are no strict recommendations regarding the content of micronutrients and their modifications in the presence of chronic kidney disease (CKD). Therefore, we decided to investigate whether T2DM patients, including those with CKD, have different levels of chromium, nickel, cobalt, magnesium, and zinc in various blood elements compared to healthy individuals.
METHODS
We divided our subjects into three groups: the control group (individuals without T2DM and proper renal function), those with T2DM and proper renal function, and those with T2DM and GFR < 60 mL/min/1.73 m.
RESULTS
We observed higher levels of chromium in all materials examined in patients with T2DM and impaired renal function. Both study groups found higher levels of nickel in samples of whole blood and red blood cells. Patients with T2DM and proper renal function had higher levels of serum manganese. Both study groups had lower levels of serum zinc. We observed higher levels of chromium in all materials examined in patients with T2DM and impaired renal function. Both study groups found higher levels of nickel in samples of whole blood and red blood cells. Patients with T2DM and proper renal function had higher levels of serum manganese. Both study groups had lower levels of serum zinc.
CONCLUSIONS
In order to ensure effective care for patients with T2DM, it is necessary to improve the standard diet, including the content of micronutrients and their modification in patients with concomitant CKD.
背景
适当的饮食是治疗 2 型糖尿病（T2DM）的基础。然而，对于慢性肾脏病（CKD）患者存在的微量营养素及其修饰物的含量，目前并没有严格的推荐意见。因此，我们决定研究 T2DM 患者，包括 CKD 患者，与健康个体相比，在各种血液成分中是否存在不同水平的铬、镍、钴、镁和锌。
方法
我们将研究对象分为三组：对照组（无 T2DM 且肾功能正常者）、T2DM 且肾功能正常者和 T2DM 且 GFR < 60 mL/min/1.73 m 者。
结果
我们观察到肾功能受损的 T2DM 患者的所有检测材料中的铬水平均升高。两组研究对象的全血和红细胞样本中的镍水平均升高。T2DM 且肾功能正常者的血清锰水平升高。两组研究对象的血清锌水平均降低。我们观察到肾功能受损的 T2DM 患者的所有检测材料中的铬水平均升高。两组研究对象的全血和红细胞样本中的镍水平均升高。T2DM 且肾功能正常者的血清锰水平升高。两组研究对象的血清锌水平均降低。
结论
为了确保对 T2DM 患者进行有效的护理，有必要改善标准饮食，包括合并 CKD 患者的微量营养素含量及其修饰物。
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