Chen Shiying, Huang Li, Liang Meili, Xie Yajing, Zhou Zhimei, Ke Yumin, Wu Zhuna
Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
Front Mol Biosci. 2024 Aug 30;11:1429852. doi: 10.3389/fmolb.2024.1429852. eCollection 2024.
Borderline ovarian tumors (BOTs), which are a special type of epithelial tumor of the ovary, lie between benign and malignant tumors and have low malignant potential. Due to the fact that the early symptoms of these tumors are relatively subtle, they are not easy to diagnose clinically. This study explores advancements in clinical detection methods and provides a comprehensive overview of molecules such as cell migration factors, cell transcription factors, cell damage repair factors, cell cycle regulators, and tumor suppressor genes that are related to the development of BOTs and their related mechanisms in recent years, thus aiming to provide more sensitive, specific, and efficient differential diagnosis and treatment plans for patients to improve their prognosis and survival outcomes.
卵巢交界性肿瘤(BOTs)是卵巢上皮性肿瘤的一种特殊类型,介于良性和恶性肿瘤之间,恶性潜能较低。由于这些肿瘤的早期症状相对隐匿,临床上不易诊断。本研究探讨了临床检测方法的进展,并全面概述了近年来与BOTs发生发展及其相关机制有关的细胞迁移因子、细胞转录因子、细胞损伤修复因子、细胞周期调节因子和肿瘤抑制基因等分子,旨在为患者提供更敏感、特异和有效的鉴别诊断及治疗方案,以改善其预后和生存结局。