抑制聚（ADP - 核糖）聚合酶会导致烷基化的HeLa细胞中DNA链断裂增加，而不会减少链的重新连接。
Inhibition of poly(ADP-ribose)polymerase causes increased DNA strand breaks without decreasing strand rejoining in alkylated HeLa cells.
作者信息
Moran M F, Ebisuzaki K
出版信息
FEBS Lett. 1985 Oct 14;190(2):279-82. doi: 10.1016/0014-5793(85)81300-4.
PMID:3930294
Abstract
Treatment of alkylated HeLa cells with 3-aminobenzamide, an inhibitor of poly(ADP-ribose) polymerase, increased the number of DNA strand breaks but did not affect the rate of strand rejoining. This suggests that an increase in DNA incision, not a decrease in ligation, results from the inhibition of poly(ADP-ribose) polymerase in cells recovering from DNA damaged by alkylating agents.
摘要
用聚（ADP - 核糖）聚合酶抑制剂3 - 氨基苯甲酰胺处理烷基化的HeLa细胞，会增加DNA链断裂的数量，但不影响链重新连接的速率。这表明，在从烷基化剂造成的DNA损伤中恢复的细胞中，聚（ADP - 核糖）聚合酶的抑制导致的是DNA切口增加，而非连接减少。
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