Tan Xin, Xiang Yu, Shi Jianyou, Chen Lu, Yu Dongke
Department of Pharmacy, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.
Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.
J Pharm Anal. 2024 Sep;14(9):100979. doi: 10.1016/j.jpha.2024.100979. Epub 2024 Apr 18.
The sodium taurocholate co-transporting polypeptide (NTCP), a bile acids transporter, has been identified as a new therapeutic target for the treatment of liver disease. This paper thoroughly investigates the function of NTCP for regulating bile acid regulation, its correlation with hepatitis B and D infections, and its association with various liver diseases. Additionally, in this review we examine recent breakthroughs in creating NTCP inhibitors and their prospective applications in liver disease treatment. While this review emphasizes the promising potential of targeting NTCP, it concurrently underscores the need for broader and more detailed research to fully understand the long-term implications and potential side effects associated with NTCP inhibition.
牛磺胆酸钠共转运多肽（NTCP）是一种胆汁酸转运蛋白，已被确定为治疗肝脏疾病的新治疗靶点。本文深入研究了NTCP在调节胆汁酸方面的功能、其与乙型和丁型肝炎感染的相关性以及与各种肝脏疾病的关联。此外，在本综述中，我们研究了创建NTCP抑制剂的最新突破及其在肝病治疗中的潜在应用。虽然本综述强调了靶向NTCP的广阔前景，但同时也强调需要进行更广泛、更详细的研究，以充分了解与NTCP抑制相关的长期影响和潜在副作用。
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