一种G3P[3]型蝙蝠轮状病毒可感染培养的人胆管细胞，并在乳鼠中引发胆道闭锁症状。

A G3P[3] bat rotavirus can infect cultured human cholangiocytes and cause biliary atresia symptom in suckling mice.

作者信息

Hao Pengfei, Pang Zhaoxia, Qu Qiaoqiao, Cui Chunmei, Jiang Yuhang, Chen Jing, Gao Zihan, Xu Zhiqiang, Li Letian, Jin Ningyi, Li Chang

机构信息

State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, 130062, China; Research Unit of Key Technologies for Prevention and Control of Virus Zoonoses, Chinese Academy of Medical Sciences, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China.

Research Unit of Key Technologies for Prevention and Control of Virus Zoonoses, Chinese Academy of Medical Sciences, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China.

出版信息

Virol Sin. 2024 Dec;39(6):974-976. doi: 10.1016/j.virs.2024.09.009. Epub 2024 Sep 24.

DOI:10.1016/j.virs.2024.09.009

PMID:39326847

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11738784/

Abstract

• Bat rotavirus strain MSLH14 (G3P[3]) can infect human cholangiocytes . • MSLH14 can cause suckling mice biliary atresia symptom, indicating potential public health risks. • MSLH14 have the potential for establishing a biliary atresia animal model.

摘要

• 蝙蝠轮状病毒株MSLH14（G3P[3]）可感染人胆管细胞。

• MSLH14可导致乳鼠出现胆道闭锁症状，提示存在潜在的公共卫生风险。

• MSLH14有建立胆道闭锁动物模型的潜力。