哺乳动物内耳驻留免疫细胞：范围综述。
Mammalian Inner Ear-Resident Immune Cells-A Scoping Review.
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Faculty of Medicine and Health Sciences, University of Zielona Góra, 65-046 Zielona Góra, Poland.
出版信息
Cells. 2024 Sep 12;13(18):1528. doi: 10.3390/cells13181528.
BACKGROUND
Several studies have demonstrated the presence of resident immune cells in the healthy inner ear.
AIM
This scoping review aimed to systematize this knowledge by collecting the data on resident immune cells in the inner ear of different species under steady-state conditions.
METHODS
The databases PubMed, MEDLINE (Ovid), CINAHL (EBSCO), and LIVIVO were used to identify articles. Systematic reviews, experimental studies, and clinical data in English and German were included without time limitations.
RESULTS
The search yielded 49 eligible articles published between 1979 and 2022. Resident immune cells, including macrophages, lymphocytes, leukocytes, and mast cells, have been observed in various mammalian inner ear structures under steady-state conditions. However, the physiological function of these cells in the healthy cochlea remains unclear, providing an opportunity for basic research in inner ear biology.
CONCLUSIONS
This review highlights the need for further investigation into the role of these cells, which is crucial for advancing the development of therapeutic methods for treating inner ear disorders, potentially transforming the field of otolaryngology and immunology.
背景
多项研究已经证实，健康内耳中存在固有免疫细胞。
目的
本范围综述旨在通过收集不同物种在稳态条件下内耳固有免疫细胞的数据，来系统地阐述这方面的知识。
方法
使用 PubMed、MEDLINE（Ovid）、CINAHL（EBSCO）和 LIVIVO 数据库来识别文章。纳入了无时间限制的英文和德文的系统评价、实验研究和临床数据。
结果
检索到 1979 年至 2022 年间发表的 49 篇符合条件的文章。在稳态条件下，已在各种哺乳动物内耳结构中观察到固有免疫细胞，包括巨噬细胞、淋巴细胞、白细胞和肥大细胞。然而，这些细胞在健康耳蜗中的生理功能仍不清楚，为内耳生物学的基础研究提供了机会。
结论
本综述强调了需要进一步研究这些细胞的作用，这对于开发治疗内耳疾病的治疗方法至关重要，可能会改变耳鼻喉科学和免疫学领域。
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