Mateos Sanchez Cristina, Quintanilla Lazaro Elvira, Rabago Luis Ramon
Department of Gastroenterological, Severo Ochoa Hospital, Madrid, Leganes 28911, Spain.
Department of Gastroenterology, San Rafael Hospital, Madrid 28016, Spain.
World J Gastrointest Endosc. 2024 Sep 16;16(9):502-508. doi: 10.4253/wjge.v16.i9.502.
Approximately 7% of the polyps resected endoscopically have an adenocarcinoma focus, with no previous endoscopic evidence of malignancy. This raises the question of whether endoscopic resection has been curative. Furthermore, there is no consensus on what the endoscopic and histological criteria for good prognosis are, the appropriate follow-up strategy and what are the long-term results. The aim of the retrospective study by Fábián was to evaluate the occurrence of local relapse or distant metastasis in those tumors that were resected endoscopically compared to those that underwent oncologic surgery. They concluded that, regardless of the treatment strategy chosen, there was a higher recurrence rate than described in the literature and that adherence to follow-up was poor. The management approach for an endoscopically benign polyp histologically confirmed as adenocarcinoma depends on the presence of any of the previously described poor prognostic histological factors. If none of these factors are present and the polyp has been completely resected (R0), active surveillance is considered appropriate as endoscopic resection is deemed curative. These results highlight, once again, the need for further multicentric clinical practice studies to obtain more evidence for the purpose of establishing appropriate treatment and follow-up strategies.
经内镜切除的息肉中约7%存在腺癌病灶,之前并无内镜下恶性肿瘤的证据。这就引发了内镜切除是否已治愈的问题。此外,对于良好预后的内镜和组织学标准是什么、合适的随访策略是什么以及长期结果如何,目前尚无共识。法比安进行的这项回顾性研究的目的是评估与接受肿瘤手术的患者相比,经内镜切除的肿瘤发生局部复发或远处转移的情况。他们得出的结论是,无论选择何种治疗策略,复发率均高于文献报道,且随访依从性较差。对于经组织学确诊为腺癌但内镜检查为良性的息肉,其管理方法取决于是否存在上述任何不良预后的组织学因素。如果不存在这些因素且息肉已完全切除(R0),则考虑进行主动监测,因为内镜切除被认为是治愈性的。这些结果再次凸显了开展进一步多中心临床实践研究的必要性,以便为制定合适的治疗和随访策略获取更多证据。