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Lymph node metastases and recurrence in pT1 colorectal cancer: Prediction with the International Budding Consortium Score-A retrospective, multi-centric study.pT1期结直肠癌的淋巴结转移与复发:采用国际萌芽联盟评分进行预测——一项回顾性多中心研究
United European Gastroenterol J. 2024 Apr;12(3):299-308. doi: 10.1002/ueg2.12521. Epub 2024 Jan 9.
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Deep Submucosal Invasion Is Not an Independent Risk Factor for Lymph Node Metastasis in T1 Colorectal Cancer: A Meta-Analysis.深度黏膜下浸润不是 T1 结直肠癌淋巴结转移的独立危险因素:一项荟萃分析。
Gastroenterology. 2022 Jul;163(1):174-189. doi: 10.1053/j.gastro.2022.04.010. Epub 2022 Apr 15.
4
Relevance of polyp size for primary endoscopic full-thickness resection of suspected T1 colorectal cancers.息肉大小与疑似 T1 结直肠肿瘤的内镜全层切除术的相关性。
Endoscopy. 2022 Nov;54(11):1062-1070. doi: 10.1055/a-1790-5539. Epub 2022 Mar 7.
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Colorectal malignant polyps: a modern approach.结直肠恶性息肉:一种现代治疗方法。
Ann Gastroenterol. 2022 Jan-Feb;35(1):17-27. doi: 10.20524/aog.2021.0681. Epub 2021 Dec 6.
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Endoscopic full-thickness resection of T1 colorectal cancers: a retrospective analysis from a multicenter Dutch eFTR registry.T1期结直肠癌的内镜全层切除术:来自荷兰多中心内镜全层切除术登记处的回顾性分析
Endoscopy. 2022 May;54(5):475-485. doi: 10.1055/a-1637-9051. Epub 2022 Jan 12.
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A Liquid Biopsy Assay for Noninvasive Identification of Lymph Node Metastases in T1 Colorectal Cancer.液体活检在 T1 结直肠癌中用于非侵入性识别淋巴结转移的检测。
Gastroenterology. 2021 Jul;161(1):151-162.e1. doi: 10.1053/j.gastro.2021.03.062. Epub 2021 Apr 2.
8
Scandinavian surveillance follow-up programmes in patients with malignant colorectal polyps.斯堪的纳维亚地区对恶性大肠息肉患者的监测随访项目。
Dan Med J. 2021 Jan 15;68(2):A07200559.
9
Risk and Time Pattern of Recurrences After Local Endoscopic Resection of T1 Colorectal Cancer: A Meta-analysis.T1期结直肠癌局部内镜切除术后复发的风险及时间模式:一项Meta分析
Clin Gastroenterol Hepatol. 2022 Feb;20(2):e298-e314. doi: 10.1016/j.cgh.2020.11.032. Epub 2020 Dec 1.
10
Endoscopic Recognition and Management Strategies for Malignant Colorectal Polyps: Recommendations of the US Multi-Society Task Force on Colorectal Cancer.结直肠癌恶性息肉的内镜识别与管理策略:美国结直肠癌多学会特别工作组的建议
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在T1期伴有癌的息肉中实施后,我们能期望监测策略有多安全?

How secure can we expect the surveillance policies to be after the implementation in T1 polyps with carcinoma?

作者信息

Mateos Sanchez Cristina, Quintanilla Lazaro Elvira, Rabago Luis Ramon

机构信息

Department of Gastroenterological, Severo Ochoa Hospital, Madrid, Leganes 28911, Spain.

Department of Gastroenterology, San Rafael Hospital, Madrid 28016, Spain.

出版信息

World J Gastrointest Endosc. 2024 Sep 16;16(9):502-508. doi: 10.4253/wjge.v16.i9.502.

DOI:10.4253/wjge.v16.i9.502
PMID:39351175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11438583/
Abstract

Approximately 7% of the polyps resected endoscopically have an adenocarcinoma focus, with no previous endoscopic evidence of malignancy. This raises the question of whether endoscopic resection has been curative. Furthermore, there is no consensus on what the endoscopic and histological criteria for good prognosis are, the appropriate follow-up strategy and what are the long-term results. The aim of the retrospective study by Fábián was to evaluate the occurrence of local relapse or distant metastasis in those tumors that were resected endoscopically compared to those that underwent oncologic surgery. They concluded that, regardless of the treatment strategy chosen, there was a higher recurrence rate than described in the literature and that adherence to follow-up was poor. The management approach for an endoscopically benign polyp histologically confirmed as adenocarcinoma depends on the presence of any of the previously described poor prognostic histological factors. If none of these factors are present and the polyp has been completely resected (R0), active surveillance is considered appropriate as endoscopic resection is deemed curative. These results highlight, once again, the need for further multicentric clinical practice studies to obtain more evidence for the purpose of establishing appropriate treatment and follow-up strategies.

摘要

经内镜切除的息肉中约7%存在腺癌病灶,之前并无内镜下恶性肿瘤的证据。这就引发了内镜切除是否已治愈的问题。此外,对于良好预后的内镜和组织学标准是什么、合适的随访策略是什么以及长期结果如何,目前尚无共识。法比安进行的这项回顾性研究的目的是评估与接受肿瘤手术的患者相比,经内镜切除的肿瘤发生局部复发或远处转移的情况。他们得出的结论是,无论选择何种治疗策略,复发率均高于文献报道,且随访依从性较差。对于经组织学确诊为腺癌但内镜检查为良性的息肉,其管理方法取决于是否存在上述任何不良预后的组织学因素。如果不存在这些因素且息肉已完全切除(R0),则考虑进行主动监测,因为内镜切除被认为是治愈性的。这些结果再次凸显了开展进一步多中心临床实践研究的必要性,以便为制定合适的治疗和随访策略获取更多证据。