一种来自海绵内生真菌的具有细胞毒性活性的新异香豆素。
A new isocoumarin from sponge endophytic fungus with cytotoxic activity.
作者信息
Zhong Ruitong, Shi Chuanling, Wu Xiaoyun, Zou Yiting, Li Jun, Liang Yongqian
机构信息
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou, China.
College of Light Industry and Food, Zhongkai University of Agriculture and Engineering, Guangzhou, China.
出版信息
Nat Prod Res. 2024 Oct 3:1-6. doi: 10.1080/14786419.2024.2411373.
A new isocoumarin, 8-hydroxy-3-methyliscoumarin-6-yl acetate (), was isolated together with five known compounds from sponge endophytic fungus The structure of the new compound was established based on 1D and 2D NMR spectral analysis. Compounds were evaluated for their cytotoxic activities and antimicrobial activities. Compounds and display cytotoxic activities against mouse melanoma cells B16 with IC values 72.5 ± 2.6 and 1.0 ± 0.5 M, respectively. Compounds and displayed faint antimicrobial activities of , and .
从海绵内生真菌中分离出一种新的异香豆素，8-羟基-3-甲基异香豆素-6-乙酸酯（），同时还分离出五种已知化合物。基于一维和二维核磁共振光谱分析确定了新化合物的结构。对化合物进行了细胞毒性活性和抗菌活性评估。化合物和对小鼠黑色素瘤细胞B16显示出细胞毒性活性，IC值分别为72.5±2.6和1.0±0.5μM。化合物和表现出微弱的抗菌活性，抑菌圈直径分别为、和。
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