Xie Xiaolin, Wang Shuang, Chen Zhi, Yu Yifan, Hu Xiaoxue, Ma Ningning, Ji Min, Tian Ye
College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, National Laboratory of Solid State Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Chemistry and Biomedicine Innovation Center (ChemBIC), ChemBioMed Interdisciplinary Research Center at Nanjing University, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, 210023, China.
State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao, 266404, China.
Chembiochem. 2025 Jan 2;26(1):e202400670. doi: 10.1002/cbic.202400670. Epub 2024 Nov 6.
Over the last four decades, research on DNA as a functional material has primarily focused on its predictable conformation and programmable interaction. However, its low energy consumption, high responsiveness and sensitivity also make it ideal for designing specific signaling pathways, and enabling the development of molecular computers. This review mainly discusses recent advancements in the utilization of DNA nanotechnology for molecular computer, encompassing applications in storage, cryptography and logic circuits. It elucidates the challenges encountered in the application process and presents solutions exemplified by representative works. Lastly, it delineates the challenges and opportunities within this filed.
在过去的四十年里，关于DNA作为一种功能材料的研究主要集中在其可预测的构象和可编程的相互作用上。然而，它的低能耗、高响应性和敏感性也使其成为设计特定信号通路以及推动分子计算机发展的理想选择。本综述主要讨论了DNA纳米技术在分子计算机应用方面的最新进展，包括在存储、密码学和逻辑电路中的应用。它阐明了应用过程中遇到的挑战，并以代表性作品为例提出了解决方案。最后，它描绘了该领域的挑战和机遇。
