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肝移植受者胆管炎一例

A Case of Cholangitis in A Liver Transplant Recipient.

作者信息

De Coster Daan A, Carroll Melissa, Lavender James, Gibson Robert

机构信息

Gastroenterology Department, John Hunter Hospital, Newcastle, Australia.

School of Medicine and Public Health, University of Newcastle, Newcastle, Australia.

出版信息

Eur J Case Rep Intern Med. 2024 Sep 6;11(10):004758. doi: 10.12890/2024_004758. eCollection 2024.

Abstract

BACKGROUND

We present the first documented case of bacteraemia in a patient with liver transplantation. is a Gram-negative anaerobic bacterium found in aquatic environments in fish and birds, and is source of nosocomial infection causing pneumonia, enteritis, cholangitis or urinary infections, associated with surgical interventions in a hospital setting.

CASE DESCRIPTION

A 44-year-old female presented with a 2-day history of fever, rigors, and headache. Her past medical history was significant for having received three orthotopic liver transplants due to Wilson's disease over a 20-year period. Her physical examination was unremarkable besides stigmata of prior liver transplantation. Blood tests revealed mild elevations in liver function markers and raised inflammatory markers. was eventually isolated from blood cultures. Subsequent magnetic resonance cholangiopancreatography (MRCP) demonstrated new left intrahepatic ductal dilation with heterogeneous peripheral enhancement. The proximal location of the cholangitis explained the lack of abdominal pain or tenderness. The patient was treated with appropriate antibiotic therapy and cultures were negative on day 2. The patient recovered without further intervention.

CONCLUSION

Seldom encountered is uncommonly pathogenic but should be considered in patients receiving immunosuppressants and those with complex surgical anatomy.

LEARNING POINTS

This is the first case of Raoultella cholangitis in a liver transplant recipient described in the literature.Atypical clinical presentation and atypical infections are common in this patient group.Cholangitis should be suspected in all liver transplant recipients due to immunosuppression.

摘要

背景

我们报告首例有文献记载的肝移植患者发生菌血症的病例。拉乌尔菌是一种革兰氏阴性厌氧菌,存在于鱼类和鸟类的水生环境中,是医院感染的来源,可导致肺炎、肠炎、胆管炎或尿路感染,与医院环境中的手术干预有关。

病例描述

一名44岁女性,有2天发热、寒战和头痛病史。她过去的病史因威尔逊病在20年内接受了3次原位肝移植而具有重要意义。除了既往肝移植的体征外,她的体格检查无异常。血液检查显示肝功能指标轻度升高,炎症指标升高。最终从血培养中分离出拉乌尔菌。随后的磁共振胰胆管造影(MRCP)显示左肝内胆管新出现扩张,外周强化不均匀。胆管炎的近端位置解释了腹痛或压痛的缺乏。患者接受了适当的抗生素治疗,第2天培养结果为阴性。患者未经进一步干预即康复。

结论

拉乌尔菌很少见,致病性不常见,但在接受免疫抑制剂治疗的患者和手术解剖结构复杂的患者中应予以考虑。

学习要点

这是文献中描述的首例肝移植受者发生拉乌尔菌胆管炎的病例。该患者群体中非典型临床表现和非典型感染很常见。由于免疫抑制,所有肝移植受者均应怀疑胆管炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/669b/11451840/2f7ea5e93203/4758_Fig1.jpg

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