Comment on - "Access to Meckel's cave for biopsies of indeterminate lesions: a systematic review".

Accessing Meckel's cave for biopsies of indeterminate lesions presents significant surgical challenges. This systematic review evaluates various approaches, with a focus on minimally invasive endoscopic techniques. A review of 75 studies reveals that the endoscopic endonasal transpterygoid approach offers improved visualization, reduced morbidity, and favorable outcomes, as demonstrated by an illustrative case of diffuse large B-cell lymphoma. While promising, further studies are needed to assess long-term efficacy and patient outcomes, and comparative research between endoscopic and traditional approaches is recommended for future investigation.