Ghosh J, Das S
Jpn J Cancer Res. 1985 Dec;76(12):1174-8.
A comparative study has been made on the levels of vitamins A and C in normal and malignant conditions in human and murine subjects. Further, the effect of supplemental vitamins A and C on tumor take, host-survival and tumor growth have been studied in a number of transplantable and induced tumors in mice. The vitamins were assayed in sera samples from normal subjects, patients with cancer of the uterine cervix or ovary, and leukemia and lymphoma patients. Among the murine group the tumors included sarcoma 180 in solid and ascitic form, benzo[a]pyrene-induced fibrosarcoma, Dalton's ascitic lymphoma and Schwartz lymphoblastic leukemia. The serum level of vitamin C was found to be lower than that of the normal controls in all cases studied. The level of vitamin A was found to be higher in cancer patients in the human group and lower in the murine group when compared with their normal controls. Studies on murine tumors showed that supplementary vitamins administered at the initial phase of tumor development reduced the percentage tumor take and the rate of tumor growth, and improved host survival, indicating that these vitamins have a protective role in the murine system.
对人类和小鼠正常及恶性状态下维生素A和C的水平进行了一项比较研究。此外，还研究了补充维生素A和C对小鼠多种可移植性肿瘤和诱导性肿瘤的肿瘤接种、宿主存活及肿瘤生长的影响。对正常受试者、子宫颈癌或卵巢癌患者以及白血病和淋巴瘤患者的血清样本进行了维生素检测。在小鼠组中，肿瘤包括实体和腹水形式的肉瘤180、苯并[a]芘诱导的纤维肉瘤、道尔顿腹水淋巴瘤和施瓦茨淋巴细胞白血病。在所研究的所有病例中，维生素C的血清水平均低于正常对照组。与正常对照组相比，人类癌症患者中维生素A水平较高，而小鼠组中维生素A水平较低。对小鼠肿瘤的研究表明，在肿瘤发展初期给予补充维生素可降低肿瘤接种百分比和肿瘤生长速率，并提高宿主存活率，这表明这些维生素在小鼠系统中具有保护作用。
