Institute of Cardiovascular Science, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China; Department of Medical Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Institute of Cardiovascular Science, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China; Department of Medical Laboratory Animal Science, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, China.
Redox Biol. 2024 Nov;77:103379. doi: 10.1016/j.redox.2024.103379. Epub 2024 Oct 4.
Histone deacetylases (HDACs) play critical roles in cardiovascular diseases (CVDs). In addition, reactive oxygen species (ROS) produced by NADPH oxidases (NOXs) exert damaging effects due to oxidative stress on heart and blood vessels. Although NOX-dependent ROS production is implicated in pathogenesis, the relationship between HDACs and NOXs in CVDs remains to be elucidated. Here, we present an overview of the regulatory effects and interconnected signaling pathways of HDACs and NOXs in CVDs. Improved insights into these relationships will facilitate the discovery of novel therapeutic agents that target HDACs, oxidase stress pathways, and the interactions between these systems which may be highly effective in the prevention and treatment of cardiovascular disorders.
组蛋白去乙酰化酶（HDACs）在心血管疾病（CVDs）中发挥着关键作用。此外，NADPH 氧化酶（NOXs）产生的活性氧（ROS）由于对心脏和血管的氧化应激而产生破坏性影响。尽管 NOX 依赖性 ROS 的产生与发病机制有关，但 HDACs 和 NOXs 在 CVDs 中的关系仍有待阐明。在这里，我们概述了 HDACs 和 NOXs 在 CVDs 中的调节作用和相互关联的信号通路。深入了解这些关系将有助于发现新的治疗药物，这些药物可以靶向 HDACs、氧化酶应激途径以及这些系统之间的相互作用，这可能在预防和治疗心血管疾病方面非常有效。
