曲妥珠单抗-恩杂鲁胺相关的过敏性紫癜报告。
Report of Henoch-Schönlein purpura associated with trastuzumab emtansine.
作者信息
Escobar-Dávila Santiago Leandro, Rivas-Tafurt Giovanna Patricia, Melo-Burbano Luis Álvaro, Osorio-Toro Luis Miguel, Benítez-Escobar Edith Norela, Galindes-Casanova Duván Arley, Izquierdo-Loaiza Jorge Hernán, Cárdenas-Perilla Rodrigo Andrés, la Hoz Carlos Orozco-de
机构信息
Facultad de Salud, Especialización en Medicina Interna, Universidad Santiago de Cali, Cali, Colombia.
Departamento de Investigación y Educación, Clínica de Occidente, Cali 760046, Colombia.
出版信息
Ecancermedicalscience. 2024 Jul 30;18:1732. doi: 10.3332/ecancer.2024.1732. eCollection 2024.
Vasculitides are a set of pathologies that can affect one or several organs, in the short and long term. They are associated with various etiologies, among which paraneoplastic syndromes and medications stand out. Although everyday cancer therapies are more directed against a therapeutic target, their use can cause a wide spectrum of complications. Some treatments against human epidermal growth factor 2 (HER2) have been associated with cutaneous and pulmonary vasculitis. We present the first case of Henoch-Schönlein purpura associated with the use of T-DM1 in a patient with HER2 breast cancer.
血管炎是一组在短期和长期内可影响一个或多个器官的病症。它们与多种病因相关，其中副肿瘤综合征和药物最为突出。尽管日常癌症治疗更多地针对治疗靶点，但它们的使用可能会引发广泛的并发症。一些针对人表皮生长因子2（HER2）的治疗与皮肤和肺部血管炎有关。我们报告了首例在HER2阳性乳腺癌患者中使用曲妥珠单抗-美坦新偶联物（T-DM1）引发的过敏性紫癜病例。
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