2 型糖尿病患者血清 Metrnl 水平与高密度脂蛋白胆固醇的相关性：一项横断面研究。
Association of serum Metrnl levels and high-density lipoprotein cholesterol in patients with type 2 diabetes mellitus: a cross-sectional study.
机构信息
Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, Shanghai, China.
Department of Endocrinology, Shanghai East Hospital, Ji'An Hospital, Jiangxi, Ji'An, China.
出版信息
PeerJ. 2024 Oct 14;12:e18264. doi: 10.7717/peerj.18264. eCollection 2024.
PURPOSE
Meteorin-like (Metrnl) is a novel adipokine which is highly expressed in adipose tissue and has a beneficial effect on glucose and lipid metabolism. High density lipoprotein cholesterol (HDL-C) is well recognized to be inversely associated with cardiovascular events. However, the relationship between serum Metrnl levels and HDL-C in the type 2 diabetes mellitus (T2DM) remains unclear. Therefore, the present study aimed to evaluate the association of serum Metrnl with HDL-C levels in T2DM.
MATERIALS AND METHODS
Eighty participants with T2DM were included in this cross-sectional study. They were divided into two groups according to HDL-C levels: Group1 (lower HDL-C group): HDL-C < 1.04 mmol/L; Group2 (higher HDL-C group): HDL-C ≥ 1.04 mmol/L. Serum Metrnl levels were measured by enzyme-linked immunosorbent assay (ELISA).
RESULTS
As compared with lower HDL-C levels groups, serum Metrnl levels were significantly higher in the group with higher HDL-C. Binary logistic regression analysis showed serum Metrnl levels were positively associated with HDL-C group after adjustment with sex, age, body mass index (BMI), mean arterial pressure (MAP), fasting blood glucose (FPG), triglyceride (TG). Furthermore, serum Metrnl levels were inversely correlated with insulin resistance index (HOMA-IR). HDL-C levels were lowest in the group with the lowest Metrnl levels group and remained positively associated with Metrnl after adjustment for sex, age, BMI, TG, and HOMA-IR by using multivariate logistic regression analysis.
CONCLUSION
Serum Metrnl levels were positively associated with HDL-C levels in patients with T2DM.This suggests that increasing serum Metrnl levels maybe a candidate for improving lipid metabolism and preventing cardiovascular events in T2DM.
REGISTRY AND THE REGISTRATION NO OF THE STUDY/TRIAL: The study was registered in the Chinese clinical trial registry (ChiCTR- 2100047148).
目的
脂肪因子 Meteorin-like（Metrnl）在脂肪组织中高度表达，对葡萄糖和脂质代谢具有有益作用。高密度脂蛋白胆固醇（HDL-C）与心血管事件呈负相关已得到广泛认可。然而，2 型糖尿病（T2DM）患者血清 Metrnl 水平与 HDL-C 之间的关系尚不清楚。因此，本研究旨在评估血清 Metrnl 与 T2DM 患者 HDL-C 水平之间的关系。
材料和方法
本横断面研究纳入了 80 例 T2DM 患者。根据 HDL-C 水平将其分为两组：组 1（低 HDL-C 组）：HDL-C<1.04mmol/L；组 2（高 HDL-C 组）：HDL-C≥1.04mmol/L。采用酶联免疫吸附试验（ELISA）检测血清 Metrnl 水平。
结果
与低 HDL-C 组相比，高 HDL-C 组血清 Metrnl 水平显著升高。二元逻辑回归分析显示，在校正性别、年龄、体重指数（BMI）、平均动脉压（MAP）、空腹血糖（FPG）、甘油三酯（TG）后，血清 Metrnl 水平与 HDL-C 呈正相关。此外，血清 Metrnl 水平与胰岛素抵抗指数（HOMA-IR）呈负相关。在多元逻辑回归分析中，血清 Metrnl 水平最低的组 HDL-C 水平最低，且在校正性别、年龄、BMI、TG 和 HOMA-IR 后仍与 Metrnl 呈正相关。
结论
T2DM 患者血清 Metrnl 水平与 HDL-C 水平呈正相关。这表明增加血清 Metrnl 水平可能是改善 T2DM 患者脂质代谢和预防心血管事件的候选方法。
注册与研究/试验注册号：该研究在中国临床试验注册中心（ChiCTR-2100047148）注册。
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