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B型主动脉夹层的管理:指南与系统评价的叙述性综述

Type B Aortic Dissection Management: A Narrative Review of Guidelines and Systematic Reviews.

作者信息

Ghimire Samir, Arghami Arman, Masood Shah Aresha, Billoo Marium, Billoo Rehan, Zarenezhad Mohammad, Iqbal Asra, Ahmadnezhad Somayeh, Maleki Fatemeh, Rezvani Kakhki Behrang, Sadrzadeh Sayyed Majid, Mehrpour Somayeh, Farzaneh Roohie, Yaqoob Uzair

机构信息

Carribean Medical University, Willemstad, Curacao.

Cardiovascular Surgery Department, Mayo Clinic, Rochester, Minnesota, USA.

出版信息

Galen Med J. 2023 Dec 18;12:e2967. doi: 10.31661/gmj.v12i.2967. eCollection 2023.

Abstract

BACKGROUND

Surgical or medical treatment for type B or descending aortic dissections with difficult presentation or stable hemodynamics is debatable. This study aimed to review the type B aortic dissection therapy to assess safety and effectiveness.

MATERIALS AND METHODS

Online databases of PubMed, Science Direct, Web of Science, Cochrane, and Scopus were searched for relevant systematic reviews, guidelines, and meta-analysis studies on the management of type B aortic dissection, up to July 2023. The conclusions were qualitatively synthesized.

RESULTS

Best medical therapy (BMT], thoracic aortic endovascular repair (TEVAR), and open surgeries (OS) were management approaches. Hemodynamics classify type B aortic dissection as complex or simple. Both examples reveal decreased in-hospital all-cause mortality with TAVR than OS. Guidelines recommend TEVAR for difficult situations and OS if it fails. Complication analyses favour TEVAR, however left subclavian artery coverage without revascularization increases stroke risk. Studies show Type B aortic dissection is simpler than TEVAR and BMT. Acute or subacute presentation did not affect reintervention rates between treatments. TEVAR had a greater early stroke risk than BMT but a decreased long-term aortic-related and all-cause mortality. The best data showed no differences in in-hospital mortality or early re-intervention between regimens. BMT reduced early stroke but increased late all-cause death.

CONCLUSION

In conclusion, addressing Type B aortic dissection is complicated, depending on presentation and hemodynamics. TEVAR is best for difficult patients, however BMT and OS also work. TEVAR may reduce in-hospital mortality but increase early stroke risk.

摘要

背景

对于表现复杂或血流动力学稳定的B型或降主动脉夹层,采用手术治疗还是药物治疗存在争议。本研究旨在回顾B型主动脉夹层的治疗方法,以评估其安全性和有效性。

材料与方法

检索了PubMed、Science Direct、Web of Science、Cochrane和Scopus等在线数据库,查找截至2023年7月有关B型主动脉夹层治疗的相关系统评价、指南和荟萃分析研究。对结论进行了定性综合分析。

结果

最佳药物治疗(BMT)、胸主动脉腔内修复术(TEVAR)和开放手术(OS)是治疗方法。根据血流动力学情况,B型主动脉夹层可分为复杂型或简单型。两种情况均显示,与开放手术相比,经导管主动脉瓣置换术(TAVR)可降低院内全因死亡率。指南推荐在困难情况下采用TEVAR,若TEVAR失败则采用开放手术。并发症分析显示TEVAR更具优势,然而,未进行血管重建的左锁骨下动脉覆盖会增加中风风险。研究表明,B型主动脉夹层比TEVAR和BMT更简单。急性或亚急性表现并不影响不同治疗方法之间的再次干预率。TEVAR早期中风风险高于BMT,但长期主动脉相关死亡率和全因死亡率降低。现有最佳数据显示,不同治疗方案在院内死亡率或早期再次干预方面无差异。BMT可降低早期中风风险,但会增加晚期全因死亡风险。

结论

总之,B型主动脉夹层的治疗较为复杂,取决于临床表现和血流动力学情况。TEVAR对困难患者最为适用,不过BMT和开放手术也有效。TEVAR可能会降低院内死亡率,但会增加早期中风风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4bd5/11491120/e4d4947d9bdf/GMJ-12-e2967-g1.jpg

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