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HIV相关性心肌病(HIVAC):发展中国家被忽视的HIV并发症。

HIVAC (HIV-associated cardiomyopathy): An overlooked complication of HIV in developing countries.

作者信息

Kharel Manish, Subedi Anukul, Hossain Md Fahad

机构信息

Kathmandu Medical College Sinamangal Kathmandu Nepal.

Ministry of Health and Family Welfare Dhaka Bangladesh.

出版信息

Clin Case Rep. 2024 Oct 21;12(10):e9483. doi: 10.1002/ccr3.9483. eCollection 2024 Oct.

Abstract

KEY CLINICAL MESSAGE

Early initiation of anti-retroviral treatment and prompt management of heart failure in a AIDS patient is crucial. If resources available endomyocardial biopsy can guide the future management.

ABSTRACT

HIV-associated cardiomyopathy (HIVAC) is a serious complication of HIV with poorly understood pathology. Systolic dysfunction was a common characteristic of HIVAC which is now replaced as diastolic dysfunction due to the availability of ART. There are various etiologies of HIVAC depending on the degree of viral replication, immune response, availability of ART, and also the disparity between high and low-income countries. We present the case report of a 65-year-old male with a past medical history of untreated HIV who came to the hospital with hemodynamic instability and was diagnosed with HIVAC with pulmonary TB, where the cause of HIVAC was poor immune response and opportunistic infection. Therefore, early cardiac monitoring is essential in HIV patients to prevent its advancement.

摘要

关键临床信息

艾滋病患者尽早开始抗逆转录病毒治疗并及时处理心力衰竭至关重要。若有资源,心内膜心肌活检可指导后续治疗。

摘要

HIV相关心肌病(HIVAC)是HIV的一种严重并发症,其病理机制尚不清楚。收缩功能障碍曾是HIVAC的常见特征,由于抗逆转录病毒治疗(ART)的应用,现在已被舒张功能障碍所取代。HIVAC有多种病因,取决于病毒复制程度、免疫反应、ART的可及性以及高收入和低收入国家之间的差异。我们报告一例65岁男性病例,其既往有未治疗的HIV病史,因血流动力学不稳定入院,被诊断为合并肺结核的HIVAC,其中HIVAC的病因是免疫反应差和机会性感染。因此,对HIV患者进行早期心脏监测对于预防病情进展至关重要。

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