Department of Urology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Front Immunol. 2024 Oct 10;15:1460275. doi: 10.3389/fimmu.2024.1460275. eCollection 2024.
The intricate roles of immune cells and inflammatory factors in cancer, particularly their association with the risk of bladder cancer, are not well understood.
This study aimed to clarify potential causal relationships between these elements and the development of bladder cancer using genome-wide association study (GWAS) summary statistics for 731 immune cell phenotypes and 91 circulating inflammatory factors (cases=2,053; controls=287,137). The primary analytical approach was Inverse Variance Weighting (IVW), supplemented by MR-Egger regression, weighted median, and weighted mode analyses. Sensitivity analyses included Cochran Q test, MR-Egger intercept test, and Leave-one-out test.
The findings indicated that monocytes are positively correlated with an increased risk of bladder cancer. On the contrary, double-negative (DN) T cells, HLA DR+CD8br, and CD28 on CD28+CD45RA+CD8br T cells exhibited an inverse correlation, suggesting a possible protective effect. Furthermore, inflammatory factors IL-20, IL-22RA1, and Eotaxin were significantly associated with an increased risk of bladder cancer.
These results suggest that certain immune cell phenotypes and inflammatory factors may play a role in the development of bladder cancer and could serve as potential biomarkers for assessing tumor risk. The findings also offer new insights into the pathogenesis of bladder cancer, indicating a need for further investigation.
免疫细胞和炎症因子在癌症中的复杂作用，特别是它们与膀胱癌风险的关联，目前尚未得到充分理解。
本研究旨在利用 731 种免疫细胞表型和 91 种循环炎症因子的全基因组关联研究（GWAS）汇总统计数据，阐明这些因素与膀胱癌发展之间的潜在因果关系（病例=2053；对照=287137）。主要分析方法为逆方差加权（IVW），并辅以 MR-Egger 回归、加权中位数和加权模式分析。敏感性分析包括 Cochran Q 检验、MR-Egger 截距检验和单样本剔除检验。
研究结果表明，单核细胞与膀胱癌风险增加呈正相关。相反，双阴性（DN）T 细胞、HLA DR+CD8br 和 CD28+CD45RA+CD8br T 细胞上的 CD28 呈负相关，提示可能具有保护作用。此外，炎症因子 IL-20、IL-22RA1 和 Eotaxin 与膀胱癌风险增加显著相关。
这些结果表明，某些免疫细胞表型和炎症因子可能在膀胱癌的发展中起作用，并可作为评估肿瘤风险的潜在生物标志物。研究结果还为膀胱癌的发病机制提供了新的见解，表明需要进一步研究。
