Yang Jie, Lin Min, Tian Xiaoyan, Li Chujun, Wu Haocun, Deng Ling, Li Xuelan, Chen Xin
Endocr Connect. 2024 Dec 13;14(1). doi: 10.1530/EC-24-0401. Print 2025 Jan 1.
Our study aimed to assess the relationship between serum adipokines and insulin resistance (IR) in women with polycystic ovary syndrome (PCOS) and explore the predictive value of adipokines on IR in PCOS.
This was a prospective cross-sectional study. 154 women with PCOS were included from July 2021 to September 2022 who underwent gonadal steroid hormone measurement, lipid profile, oral glucose tolerance test and homoeostasis model assessment (HOMA)-IR. Adiponectin (APN), leptin and secreted frizzled-related protein (Sfrp5) were measured by immunoturbidimetry and enzyme-linked immunosorbent assay. Women with PCOS were categorised based on the presence of IR.
Women with PCOS with IR (n = 99) had significantly lower APN level and APN-to-leptin ratio (A/L ratio) than those without IR (n = 55), whereas serum levels of leptin and Sfrp5 were similar between the two groups. In multivariable linear regression analysis, serum log (APN) and log (A/L ratio) were associated with log (HOMA-IR), and the association was statistically significant after adjusting for body mass index and free androgen index. The area under the receiver operating characteristic curve (95% CI) for APN and A/L ratio was 0.726 (0.644-0.807; P < 0.001) and 0.660 (0.569-0.751; P < 0.01), respectively, with cutoff values of 5.225 mg/L (Youden index ¼ 0.364) and 1.438 mg/L (Youden index ¼ 0.265).
Our study demonstrated that serum APN was negatively related to IR. Serum APN may be useful as a clinical marker for IR in women with PCOS. Our findings warrant further investigations into the function of APN in the pathogenesis of IR in women with PCOS.
本研究旨在评估多囊卵巢综合征（PCOS）女性血清脂肪因子与胰岛素抵抗（IR）之间的关系，并探讨脂肪因子对PCOS患者IR的预测价值。
这是一项前瞻性横断面研究。纳入了2021年7月至2022年9月期间的154例PCOS女性，她们接受了性腺甾体激素测定、血脂谱、口服葡萄糖耐量试验和稳态模型评估（HOMA）-IR。采用免疫比浊法和酶联免疫吸附测定法检测脂联素（APN）、瘦素和分泌型卷曲相关蛋白（Sfrp5）。根据是否存在IR对PCOS女性进行分类。
患有IR的PCOS女性（n = 99）的APN水平和APN与瘦素比值（A/L比值）显著低于无IR的女性（n = 55），而两组之间的瘦素和Sfrp5血清水平相似。在多变量线性回归分析中，血清log（APN）和log（A/L比值）与log（HOMA-IR）相关，在调整体重指数和游离雄激素指数后，该关联具有统计学意义。APN和A/L比值的受试者工作特征曲线下面积（95%CI）分别为0.726（0.644 - 0.807；P < 0.001）和0.660（0.569 - 0.751；P < 0.01），截断值分别为5.225 mg/L（约登指数 = 0.364）和1.438 mg/L（约登指数 = 0.265）。
我们的研究表明，血清APN与IR呈负相关。血清APN可能作为PCOS女性IR的临床标志物。我们的研究结果值得进一步研究APN在PCOS女性IR发病机制中的作用。
