Division of Rehabilitation, Department of Clinical Practice and Support, Hiroshima University Hospital, 1-2-3 Kasumi, Minami, Hiroshima, 734-8551, Japan.
Department of Anesthesiology and Critical Care, Hiroshima University, 1-2-3 Kasumi, Minami, Hiroshima, 734-8551, Japan.
J Med Case Rep. 2024 Oct 31;18(1):529. doi: 10.1186/s13256-024-04833-4.
Surgical treatment of pheochromocytomas is associated with circulatory dynamics instability, necessitating systemic management of the patient in the intensive care unit after surgery. Early mobilization after pheochromocytoma surgery is not described in the guidelines, and to our knowledge, no reports have specifically focused on circulatory dynamics during early mobilization after surgery.
A 31-year-old Japanese woman was diagnosed with bilateral pheochromocytoma and underwent a second-stage adrenalectomy for bilateral pheochromocytoma at our hospital. We evaluated circulatory dynamics during a passive upright posture on postoperative days 1 and 4. She was placed on a tilt bed in the supine position (0° head) for 15 min, passive upright posture (60°) for 15 min, and supine position again for 10 min. In the passive upright posture, both systolic and diastolic blood pressure decreased, and the heart rate increased by 10 bpm over approximately 10 minutes. After the postural change from the passive upright posture to the supine position, the heart rate decreased to a level lower than in the supine prior to the passive upright posture. The same measurements were taken on postoperative day 4. Systolic blood pressure decreased in the passive upright posture, but diastolic blood pressure remained unchanged. The heart rate also increased earlier after passive upright posture compared with that on the day after surgery. When the patient returned to the supine position from the passive upright posture, the heart rate decreased even further compared with its level prior to the passive upright posture, as observed on the day after surgery.
Circulatory dynamics may fluctuate after surgery for pheochromocytoma due to a relative decrease in epinephrine and norepinephrine secretion. In this case, the patient's response may be close to normal by the fourth postoperative day, but circulatory dynamics fluctuations were noted on both the first and fourth postoperative days when the patient was supine after passive upright posture. Although the substantial variability of perioperative circulatory dynamics in patients with pheochromocytoma has improved considerably with the development of perioperative management guidelines, circulatory dynamics should be carefully monitored during early mobilization and after its completion.
手术治疗嗜铬细胞瘤与循环动力学不稳定有关,因此需要在手术后将患者置于重症监护病房进行全身性管理。目前的指南中并未描述嗜铬细胞瘤手术后的早期活动,据我们所知,也没有专门针对手术后早期活动期间循环动力学的报告。
一名 31 岁的日本女性被诊断为双侧嗜铬细胞瘤,并在我院行双侧嗜铬细胞瘤二期肾上腺切除术。我们评估了术后第 1 天和第 4 天被动直立位时的循环动力学。她先仰卧于倾斜床上(0°头位)15 分钟,然后被动直立位(60°)15 分钟,再仰卧位 10 分钟。在被动直立位时,收缩压和舒张压均下降,心率增加约 10 bpm,持续约 10 分钟。从被动直立位改为仰卧位后,心率下降至低于被动直立位前的仰卧位水平。术后第 4 天进行了相同的测量。在被动直立位时收缩压下降,但舒张压保持不变。与术后第 1 天相比,被动直立位后心率更早升高。从被动直立位改为仰卧位时,心率甚至进一步下降,与术后第 1 天的被动直立位前水平相比。
由于肾上腺素和去甲肾上腺素分泌相对减少,嗜铬细胞瘤手术后循环动力学可能会波动。在这种情况下,患者的反应可能在术后第 4 天接近正常,但在术后第 1 天和第 4 天被动直立位后仰卧位时,均观察到循环动力学波动。尽管随着围手术期管理指南的发展,嗜铬细胞瘤患者围手术期循环动力学的显著变异性已经得到了很大改善,但在早期活动和活动结束后仍应仔细监测循环动力学。