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INTRODUCTION

Getah virus (GETV) is a multi-host virus found in pigs, horses, and blue foxes. Clinically, GETV can cause fever, diarrhea, and reproductive disorders in pigs, representing significant threats to pig breeding. At present, few studies have examined the pathogenicity of GETV in pigs of different ages.

METHODS

In the present study, a new strain, named GETV-QJ, was isolated from clinically ill pigs, and whole genome sequencing analysis was performed. Besides the pathogenicity of piglets and pregnant sows of this strain was further studied.

RESULTS

the results illustrated that the strain belonged to group III. The strain had 93.6%-96.3% homology with other subtypes, and its homology with the same subtype strain ranged 96.5%-99%. Further studies on the pathogenicity of the virus indicated that this strain caused severe diarrhea, fever, and intestinal and lung damage in 7-day-old piglets, resulting in their death. The piglet survival rate was 0%. In pregnant sows, this strain did not cause fever, death, or abortion, but it induced viremia, which affected the farrowing performance of sows and led to reduced piglet survival.

DISCUSSION

In this study, we isolated a highly virulent group III and comprehensively established a pathogenic model of GETV in piglets and sows, providing a reference and guidance for the prevention and control of this infection.

INTRODUCTION

METHODS

RESULTS

DISCUSSION

简介

猴痘病毒（GETV）是一种多宿主病毒，存在于猪、马和蓝狐中。临床上，GETV 可引起猪发热、腹泻和生殖障碍，对养猪业构成重大威胁。目前，关于不同年龄猪 GETV 致病性的研究较少。

方法

本研究从临床发病猪中分离出新毒株 GETV-QJ，并进行全基因组测序分析。进一步研究了该毒株对仔猪和妊娠母猪的致病性。

结果

结果表明，该株属于第三组。该株与其他亚型的同源性为 93.6%-96.3%，与同亚型株的同源性为 96.5%-99%。进一步研究该病毒的致病性表明，该毒株可引起 7 日龄仔猪严重腹泻、发热、肠肺损伤，导致仔猪死亡，仔猪存活率为 0%。在妊娠母猪中，该毒株不引起发热、死亡或流产，但可引起病毒血症，影响母猪产仔性能，导致仔猪存活率降低。