Institute of Life Sciences & Biomedical Collaborative Innovation Center of Zhejiang Province, Wenzhou University, Wenzhou, 325035, People's Republic of China.
Department of Hepatobiliary-Pancreatic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People's Republic of China.
Int J Nanomedicine. 2024 Oct 28;19:10917-10940. doi: 10.2147/IJN.S492651. eCollection 2024.
Diabetes Mellitus (DM) is a substantial health concern worldwide, and its incidence is progressively escalating. Conventional pharmacological interventions frequently entail undesirable side effects, and while probiotics offer benefits, they are hindered by constraints such as diminished stability and effectiveness within the gastrointestinal milieu. Given these complications, the advent of bioengineered probiotics is a promising alternative for DM management.
The objective of this review is to provide an exhaustive synthesis of the most recent studies on the use of engineered probiotics in the management of DM. This study aimed to clarify the mechanisms through which these probiotics function, evaluate their clinical effectiveness, and enhance public awareness of their prospective advantages in the treatment of DM.
Scholarly critiques have explored diverse methodologies of probiotic engineering, including physical alteration, bioenrichment, and genetic manipulation. These techniques augment the therapeutic potency of probiotics by ameliorating gut microbiota, fortifying the intestinal barrier, modulating metabolic pathways, and regulating immune responses. Such advancements have established engineered probiotics as a credible therapeutic strategy for DM, potentially providing enhanced results compared to conventional treatments.
糖尿病（DM）是全球范围内一个重大的健康问题，其发病率正在逐步上升。传统的药物干预常常伴随着不良反应，而益生菌虽然有好处，但由于在胃肠道环境中的稳定性和有效性降低等限制，其应用受到阻碍。鉴于这些并发症，生物工程益生菌的出现为 DM 的管理提供了一个有前途的替代方案。
本综述的目的是对最近关于工程益生菌在 DM 管理中的应用的研究进行全面综合。本研究旨在阐明这些益生菌发挥作用的机制，评估它们的临床效果，并提高公众对它们在 DM 治疗中的潜在优势的认识。
学术批评探讨了益生菌工程的多种方法，包括物理改变、生物富集和遗传操作。这些技术通过改善肠道微生物群、增强肠道屏障、调节代谢途径和调节免疫反应来提高益生菌的治疗效果。这些进展使工程益生菌成为 DM 的一种可信的治疗策略，与传统治疗相比可能提供更好的效果。
