Center for Molecular Medicine, China Medical University Hospital, Taichung, 406040, Taiwan.
Research Center for Cancer Biology, China Medical University, Taichung, 406040, Taiwan.
J Biomed Sci. 2024 Nov 4;31(1):101. doi: 10.1186/s12929-024-01089-4.
A variety of cell death pathways play critical roles in the onset and progression of multiple diseases. Paraptosis, a unique form of programmed cell death, has gained significant attention in recent years. Unlike apoptosis and necrosis, paraptosis is characterized by cytoplasmic vacuolization, swelling of the endoplasmic reticulum and mitochondria, and the absence of caspase activation. Numerous natural products, synthetic compounds, and newly launched nanomedicines have been demonstrated to prime cell death through the paraptotic program and may offer novel therapeutic strategies for cancer treatment. This review summarizes recent findings, delineates the intricate network of signaling pathways underlying paraptosis, and discusses the potential therapeutic implications of targeting paraptosis in cancer treatment. The aim of this review is to expand our understanding of this unique cell death process and explore the potential therapeutic implications of targeting paraptosis in cancer treatment.
多种细胞死亡途径在多种疾病的发生和进展中起着关键作用。细胞程序性坏死的一种独特形式，已引起近年来的广泛关注。与细胞凋亡和细胞坏死不同，细胞程序性坏死的特征是细胞质空泡化、内质网和线粒体肿胀，以及缺乏半胱天冬酶激活。许多天然产物、合成化合物和新推出的纳米药物已被证明可通过细胞程序性坏死途径引发细胞死亡，并可能为癌症治疗提供新的治疗策略。本综述总结了最近的发现，阐述了细胞程序性坏死的信号通路的复杂网络，并讨论了针对癌症治疗中细胞程序性坏死的潜在治疗意义。本综述的目的是扩展我们对这种独特的细胞死亡过程的理解，并探索针对癌症治疗中细胞程序性坏死的潜在治疗意义。
