• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

诱导细胞焦亡的生物材料为变革性抗肿瘤免疫疗法铺平道路。

Pyroptosis-Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy.

作者信息

Yin Hao, Chen Tanzhou, Hu Xiaoqu, Zhu Wenting, Li Yida, Sun Wenjie, Li Lei, Zhang Hongmei, Wang Qinyang

机构信息

Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, 325027, P. R. China.

Department of Radiation and Medical Oncology, Wenzhou Key Laboratory of Basic Science and Translational Research of Radiation Oncology, Zhejiang Engineering Research Center for Innovation and Application of Intelligent Radiotherapy Technology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325027, P. R. China.

出版信息

Adv Sci (Weinh). 2024 Dec;11(47):e2410336. doi: 10.1002/advs.202410336. Epub 2024 Nov 6.

DOI:10.1002/advs.202410336
PMID:39501932
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11653674/
Abstract

Pyroptosis can effectively overcome immunosuppression and reactivate antitumor immunity. However, pyroptosis initiation is challenging. First, the underlying biological mechanisms of pyroptosis are complex, and a variety of gasdermin family proteins can be targeted to induce pyroptosis. Second, other intracellular death pathways may also interfere with pyroptosis. The rationally designed gasdermin protein-targeting biomaterials are capable of inducing pyroptosis and have the capacity to stimulate antitumor immune function in a safe and effective manner. This review provides a comprehensive overview of the design, function, and antitumor efficacy of pyroptosis-inducing materials and the associated challenges, with a particular focus on the design options for pyroptosis-inducing biomaterials based on the activation of different gasdermin proteins. This review offers a valuable foundation for the further development of pyroptosis-inducing biomaterials for clinical applications.

摘要

细胞焦亡能够有效克服免疫抑制并重新激活抗肿瘤免疫。然而，启动细胞焦亡具有挑战性。首先，细胞焦亡的潜在生物学机制复杂，多种gasdermin家族蛋白可作为靶点来诱导细胞焦亡。其次，其他细胞内死亡途径也可能干扰细胞焦亡。合理设计的靶向gasdermin蛋白的生物材料能够诱导细胞焦亡，并具有以安全有效的方式刺激抗肿瘤免疫功能的能力。本综述全面概述了诱导细胞焦亡材料的设计、功能、抗肿瘤疗效及相关挑战，特别关注基于不同gasdermin蛋白激活的诱导细胞焦亡生物材料的设计选择。本综述为诱导细胞焦亡生物材料的进一步临床应用开发提供了有价值的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/b58a553c5e5c/ADVS-11-2410336-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/9a450283843c/ADVS-11-2410336-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/aff99c437128/ADVS-11-2410336-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/7d3a0717c5fa/ADVS-11-2410336-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/421c57a8e748/ADVS-11-2410336-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/e3dec6666ec3/ADVS-11-2410336-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/f5ebddc67a50/ADVS-11-2410336-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/62e1708694a3/ADVS-11-2410336-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/98e721d9f730/ADVS-11-2410336-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/b450baf05075/ADVS-11-2410336-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/cde4bf005169/ADVS-11-2410336-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/810bf4797024/ADVS-11-2410336-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/4cfb47685174/ADVS-11-2410336-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/5b02f6700729/ADVS-11-2410336-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/04441b4526d6/ADVS-11-2410336-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/b58a553c5e5c/ADVS-11-2410336-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/9a450283843c/ADVS-11-2410336-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/aff99c437128/ADVS-11-2410336-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/7d3a0717c5fa/ADVS-11-2410336-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/421c57a8e748/ADVS-11-2410336-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/e3dec6666ec3/ADVS-11-2410336-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/f5ebddc67a50/ADVS-11-2410336-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/62e1708694a3/ADVS-11-2410336-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/98e721d9f730/ADVS-11-2410336-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/b450baf05075/ADVS-11-2410336-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/cde4bf005169/ADVS-11-2410336-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/810bf4797024/ADVS-11-2410336-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/4cfb47685174/ADVS-11-2410336-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/5b02f6700729/ADVS-11-2410336-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/04441b4526d6/ADVS-11-2410336-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6944/11653674/b58a553c5e5c/ADVS-11-2410336-g006.jpg

相似文献

1
Pyroptosis-Inducing Biomaterials Pave the Way for Transformative Antitumor Immunotherapy.诱导细胞焦亡的生物材料为变革性抗肿瘤免疫疗法铺平道路。
Adv Sci (Weinh). 2024 Dec;11(47):e2410336. doi: 10.1002/advs.202410336. Epub 2024 Nov 6.
2
Targeting pyroptosis for cancer immunotherapy: mechanistic insights and clinical perspectives.靶向细胞焦亡用于癌症免疫治疗：机制见解与临床前景
Mol Cancer. 2025 May 3;24(1):131. doi: 10.1186/s12943-025-02344-4.
3
Nanomaterials Enhance Pyroptosis-Based Tumor Immunotherapy.纳米材料增强基于细胞焦亡的肿瘤免疫治疗。
Int J Nanomedicine. 2024 Jun 10;19:5545-5579. doi: 10.2147/IJN.S457309. eCollection 2024.
4
A dual-pathway pyroptosis inducer based on Au-CuSe@ZIF-8 enhances tumor immunotherapy by disrupting the zinc ion homeostasis.基于 Au-CuSe@ZIF-8 的双通路细胞焦亡诱导剂通过破坏锌离子稳态增强肿瘤免疫治疗。
Acta Biomater. 2024 Oct 15;188:329-343. doi: 10.1016/j.actbio.2024.09.015. Epub 2024 Sep 13.
5
Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment.解锁细胞焦亡在肿瘤免疫治疗中的潜力：癌症治疗的新领域。
Front Immunol. 2024 Jun 14;15:1381778. doi: 10.3389/fimmu.2024.1381778. eCollection 2024.
6
Nanomedicine-induced cell pyroptosis to enhance antitumor immunotherapy.纳米医学诱导细胞焦亡增强抗肿瘤免疫治疗。
J Mater Chem B. 2024 Apr 24;12(16):3857-3880. doi: 10.1039/d3tb03017b.
7
Lighting a Fire: Can We Harness Pyroptosis to Ignite Antitumor Immunity?点燃战火：我们能否利用细胞焦亡来点燃抗肿瘤免疫？
Cancer Immunol Res. 2021 Jan;9(1):2-7. doi: 10.1158/2326-6066.CIR-20-0525.
8
Logic "AND Gate Circuit"-Based Gasdermin Protein Expressing Nanoplatform Induces Tumor-Specific Pyroptosis to Enhance Cancer Immunotherapy.基于逻辑“与门电路”的 Gasdermin 蛋白表达纳米平台诱导肿瘤特异性细胞焦亡以增强癌症免疫治疗。
ACS Nano. 2024 Mar 5;18(9):6946-6962. doi: 10.1021/acsnano.3c09405. Epub 2024 Feb 20.
9
Switching from Apoptosis to Pyroptosis: Gasdermin-Elicited Inflammation and Antitumor Immunity.从细胞凋亡到细胞焦亡的转变：Gasdermin-E 诱导的炎症和抗肿瘤免疫。
Int J Mol Sci. 2021 Jan 4;22(1):426. doi: 10.3390/ijms22010426.
10
A Bioinspired Immunostimulatory System for Inducing Powerful Antitumor Immune Function by Directly Causing Plasma Membrane Rupture.一种仿生免疫刺激系统，通过直接导致细胞膜破裂来诱导强大的抗肿瘤免疫功能。
Adv Sci (Weinh). 2024 May;11(20):e2305934. doi: 10.1002/advs.202305934. Epub 2024 Mar 14.

引用本文的文献

1
Deep insight into cytokine storm: from pathogenesis to treatment.深入洞察细胞因子风暴：从发病机制到治疗。
Signal Transduct Target Ther. 2025 Apr 16;10(1):112. doi: 10.1038/s41392-025-02178-y.

本文引用的文献

1
Cancer cell metabolism and antitumour immunity.癌细胞代谢与抗肿瘤免疫。
Nat Rev Immunol. 2024 Sep;24(9):654-669. doi: 10.1038/s41577-024-01026-4. Epub 2024 Apr 22.
2
A T-Cell Inspired Sonoporation System Enhances Low-Dose X-Ray-Mediated Pyroptosis and Radioimmunotherapy Efficacy by Restoring Gasdermin-E Expression.一种 T 细胞启发的声孔系统通过恢复 GSDME 表达增强低剂量 X 射线介导的细胞焦亡和放射免疫治疗效果。
Adv Mater. 2024 Jun;36(26):e2401384. doi: 10.1002/adma.202401384. Epub 2024 Mar 29.
3
Immunogenic cell death in cancer: targeting necroptosis to induce antitumour immunity.
肿瘤中的免疫原性细胞死亡：靶向坏死性凋亡诱导抗肿瘤免疫。
Nat Rev Cancer. 2024 May;24(5):299-315. doi: 10.1038/s41568-024-00674-x. Epub 2024 Mar 7.
4
A PROTAC Augmenter for Photo-Driven Pyroptosis in Breast Cancer.一种用于光驱动乳腺癌细胞焦亡的 PROTAC 增强剂。
Adv Mater. 2024 May;36(21):e2313460. doi: 10.1002/adma.202313460. Epub 2024 Feb 22.
5
Programmed Targeting Pyruvate Metabolism Therapy Amplified Single-Atom Nanozyme-Activated Pyroptosis for Immunotherapy.靶向丙酮酸代谢的程序化治疗增强了单原子纳米酶激活的细胞焦亡用于免疫治疗。
Adv Mater. 2024 Jun;36(24):e2312124. doi: 10.1002/adma.202312124. Epub 2024 Mar 14.
6
Biodegradable Monometallic Aluminum as a Biotuner for Tumor Pyroptosis.可生物降解的单金属铝作为肿瘤细胞焦亡的生物调节剂。
Angew Chem Int Ed Engl. 2024 Mar 18;63(12):e202317304. doi: 10.1002/anie.202317304. Epub 2024 Feb 15.
7
Advancing Precision: A Controllable Self-Synergistic Nanoplatform Initiating Pyroptosis-Based Immunogenic Cell Death Cascade for Targeted Tumor Therapy.推进精准医疗：一种可控的自协同纳米平台引发基于细胞焦亡的免疫原性细胞死亡级联反应用于靶向肿瘤治疗。
ACS Nano. 2024 Jan 16;18(2):1582-1598. doi: 10.1021/acsnano.3c09499. Epub 2024 Jan 3.
8
A Self-Adaptive Pyroptosis Inducer: Optimizing the Catalytic Microenvironment of Nanozymes by Membrane-Adhered Microbe Enables Potent Cancer Immunotherapy.自适应细胞焦亡诱导剂：通过膜黏附微生物优化纳米酶的催化微环境实现有效的癌症免疫治疗。
Adv Mater. 2024 Apr;36(14):e2310063. doi: 10.1002/adma.202310063. Epub 2024 Jan 4.
9
A CTL-Inspired Killing System Using Ultralow-Dose Chemical-Drugs to Induce a Pyroptosis-Mediated Antitumor Immune Function.一种基于 CTL 的杀伤系统，使用超低剂量的化学药物诱导细胞焦亡介导的抗肿瘤免疫功能。
Adv Mater. 2024 Mar;36(13):e2309839. doi: 10.1002/adma.202309839. Epub 2023 Dec 28.
10
Platinum Prodrug Nanoparticles with COX-2 Inhibition Amplify Pyroptosis for Enhanced Chemotherapy and Immune Activation of Pancreatic Cancer.载 COX-2 抑制的顺铂前药纳米颗粒增强胰腺癌细胞焦亡作用以增强化疗和免疫激活。
Adv Mater. 2024 Mar;36(11):e2310456. doi: 10.1002/adma.202310456. Epub 2023 Dec 20.