Department of Orthopedics Huadong Hospital Affiliated to Fudan University, Shanghai 200040, China.
Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai 200040, China.
Mediators Inflamm. 2024 Aug 20;2024:3362336. doi: 10.1155/2024/3362336. eCollection 2024.
The role of C-reactive protein (CRP), an inflammatory marker, in the development of sarcopenia remains uncertain.
This cross-sectional research involved the enrollment of 207 patients, classified into two groups: 74 patients with sarcopenia and 133 patients without sarcopenia. Clinical data of the participants, including hand grip strength, walking speed, appendicular lean mass (ALM), and calf circumference, were collected and recorded. We evaluated the extent to which CRP levels are associated with the risk of sarcopenia using both univariate and multivariate logistic regression models. Besides, the correlation between CRP levels, hand grip strength, ALM, and walking speed was examined using the Spearman rank correlation test. Moreover, we have employed the Mendelian randomization (MR) analysis technique to explore the causal relationship between CRP levels and the occurrence of sarcopenia.
The sarcopenia group showed a higher proportion of older women, with significant differences in anemia prevalence, calf circumference, gait speed, ALM, hand grip strength, and elevated CRP levels compared to the control group. Logistic regression analyses identified CRP as an independent risk factor for sarcopenia (OR: 1.151, 95% CI:1.070-1.238, and < 0.001). Correlation analysis results revealed a noteworthy inverse association with hand grip strength ( = -0.454 and < 0.001), ALM ( = -0.426 and < 0.001), and walking speed ( = -0.431 and < 0.001). MR analysis provided further evidence of a significant detrimental link between genetically predicted CRP levels and essential sarcopenia characteristics, with consistent results across various statistical models.
Our study uncovered strong evidence supporting a noteworthy inverse association and causality between CRP concentrations and sarcopenia, indicating that CRP has the potential to serve as a biomarker for sarcopenia.
C 反应蛋白（CRP）作为一种炎症标志物，其在肌少症发展中的作用仍不确定。
本横断面研究纳入了 207 名患者，分为两组：肌少症组 74 例，非肌少症组 133 例。收集并记录参与者的临床数据，包括握力、步行速度、四肢瘦体重（ALM）和小腿围。使用单变量和多变量逻辑回归模型评估 CRP 水平与肌少症风险的关联程度。此外，使用 Spearman 秩相关检验评估 CRP 水平与握力、ALM 和步行速度之间的相关性。还采用孟德尔随机化（MR）分析技术探讨 CRP 水平与肌少症发生之间的因果关系。
肌少症组中年龄较大的女性比例较高，贫血患病率、小腿围、步态速度、ALM、握力和 CRP 水平显著高于对照组。逻辑回归分析确定 CRP 是肌少症的独立危险因素（OR：1.151，95%CI：1.070-1.238， < 0.001）。相关性分析结果显示，CRP 与握力（ = -0.454， < 0.001）、ALM（ = -0.426， < 0.001）和步行速度（ = -0.431， < 0.001）呈显著负相关。MR 分析进一步提供了遗传预测 CRP 水平与肌少症主要特征之间存在显著负相关的证据，且在各种统计模型中结果一致。
本研究发现 CRP 浓度与肌少症之间存在显著负相关和因果关系，有力支持了这一观点，表明 CRP 有可能成为肌少症的生物标志物。
