Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kazan, Russia.
Division of Medical and Biological Sciences, Tatarstan Academy of Sciences, 420008 Kazan, Russia.
Cells. 2024 Oct 23;13(21):1755. doi: 10.3390/cells13211755.
Currently, approaches to personalized medicine are actively developing. For example, the use of platelet-rich plasma (PRP) is actively growing every year. As a result of activation, platelets release a wide range of growth factors, cytokines, chemokines, and angiogenic factors, after which these molecules regulate chemotaxis, inflammation, and vasomotor function and play a crucial role in restoring the integrity of damaged vascular walls, angiogenesis, and tissue regeneration. Due to these characteristics, PRP has a wide potential in regenerative medicine and gerontology. PRP products are actively used not only in esthetic medicine but also to stimulate tissue regeneration and relieve chronic inflammation. PRP therapy has a number of advantages, but the controversial results of clinical studies, a lack of standardization of the sample preparation of the material, and insufficient objective data on the evaluation of efficacy do not allow us to unambiguously look at the use of PRP for therapeutic purposes. In this review, we will examine the current clinical efficacy of PRP-based products and analyze the contribution of PRP in the therapy of diseases associated with aging.
目前，个性化医疗方法正在积极发展。例如，富血小板血浆 (PRP) 的使用每年都在积极增长。在激活后，血小板释放出广泛的生长因子、细胞因子、趋化因子和血管生成因子，这些分子随后调节趋化作用、炎症和血管舒缩功能，并在恢复受损血管壁、血管生成和组织再生的完整性方面发挥关键作用。由于这些特性，PRP 在再生医学和老年医学中有广泛的应用潜力。PRP 产品不仅在美容医学中得到积极应用，而且还用于刺激组织再生和缓解慢性炎症。PRP 疗法有许多优点，但临床研究结果存在争议、材料的样本制备缺乏标准化以及对疗效评估的客观数据不足，这使得我们无法明确看待 PRP 在治疗目的上的应用。在这篇综述中，我们将检查基于 PRP 的产品的当前临床疗效，并分析 PRP 在与衰老相关的疾病治疗中的贡献。
