Negruț Roxana Loriana, Coțe Adrian, Maghiar Adrian Marius
Department of Medicine, Doctoral School of Biomedical Sciences, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania.
County Clinical Emergency Hospital Bihor, 410087 Oradea, Romania.
J Clin Med. 2024 Oct 30;13(21):6533. doi: 10.3390/jcm13216533.
Emergency surgical interventions for colon cancer are often associated with poorer outcomes compared to elective surgeries due to the advanced state of the disease and the urgency of intervention. This retrospective study aimed to evaluate the management of emergency management of colon cancer and to evaluate differences in patient outcomes. Conducted at a single surgical emergency center, the study analyzed 182 cases, focusing on demographics, tumor characteristics, surgical methods and patient outcomes. A retrospective observational study was conducted, involving 182 cases who underwent surgery for colon cancer in a single surgical emergency center. Data was collected from hospital records, encompassing demographic details, tumor characteristics, surgical intervention detail and outcomes, alongside with inflammatory profiles. Statistical analyses included descriptive statistics and -tests with standard significance at < 0.05. The study showed that emergency cases had significantly poorer in-hospital survival rates (75.42%) compared to elective surgeries. Inflammatory markers such as Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio were higher in emergency cases, suggesting heightened systemic stress. Emergency surgery was also associated with a higher incidence of ostomy and postoperative complications. Emergency surgery for colon cancer is linked to more advanced tumors, increased physiological stress and lesser clinical outcomes. Early detection strategies and active targeted screening could reduce the need for emergency interventions. Future research should focus on early diagnosis protocols and enhancing public health strategies to minimize emergency presentations, thereby leading to better outcomes for colon cancer patients.
与择期手术相比,由于结肠癌病情进展以及干预的紧迫性,结肠癌的急诊手术干预往往预后较差。这项回顾性研究旨在评估结肠癌的急诊处理方式,并评估患者预后的差异。该研究在一个单一的外科急诊中心进行,分析了182例病例,重点关注人口统计学、肿瘤特征、手术方法和患者预后。进行了一项回顾性观察研究,涉及在一个单一外科急诊中心接受结肠癌手术的182例病例。数据从医院记录中收集,包括人口统计学细节、肿瘤特征、手术干预细节和预后,以及炎症指标。统计分析包括描述性统计和显著性水平<0.05的检验。研究表明,与择期手术相比,急诊病例的院内生存率显著更低(75.42%)。急诊病例中的中性粒细胞与淋巴细胞比值、血小板与淋巴细胞比值等炎症标志物更高,表明全身应激加剧。急诊手术还与造口术和术后并发症的发生率较高有关。结肠癌的急诊手术与更晚期的肿瘤、生理应激增加和较差的临床结果相关。早期检测策略和积极的靶向筛查可以减少急诊干预的需求。未来的研究应侧重于早期诊断方案和加强公共卫生策略,以尽量减少急诊情况的发生,从而为结肠癌患者带来更好的预后。