College of Animal Science and Technology, Southwest University, Chongqing 400715, China.
Int J Mol Sci. 2024 Oct 22;25(21):11337. doi: 10.3390/ijms252111337.
Both RNA and protein play important roles in the process of gene expression and regulation, and it has been widely discussed that the interactions between RNA and protein affect gene transcription, translation efficiency, and post-translational modification. As an important class of proteins, RNA-binding proteins bind to RNA and affect gene expression in various ways. Here, we review the structural and functional properties of RNA-binding proteins and illustrate the specific modes of interactions between RNA and RNA-binding proteins and describe the involvement of some representative RNA-binding protein families in this network of action. Furthermore, we also explore the association that exists between RNA-binding proteins and the onset of diseases, as well as their potential in terms of serving as a therapeutic tool for the treatment of diseases. The in-depth exploration of the interactions between RNA and RNA-binding proteins reveals the dynamic process of gene expression and regulation, as well as offering valuable insights to advance the progress in the dissection of disease mechanisms and research and discovery of drugs, which promote the development of molecular biology.
RNA 和蛋白质在基因表达和调控过程中都发挥着重要作用，人们广泛讨论了 RNA 和蛋白质之间的相互作用如何影响基因转录、翻译效率和翻译后修饰。RNA 结合蛋白作为一类重要的蛋白质，与 RNA 结合并以各种方式影响基因表达。在这里，我们综述了 RNA 结合蛋白的结构和功能特性，并说明了 RNA 和 RNA 结合蛋白之间相互作用的特定模式，描述了一些有代表性的 RNA 结合蛋白家族在这一作用网络中的参与情况。此外，我们还探讨了 RNA 结合蛋白与疾病发生之间的关联，以及它们作为治疗疾病的工具的潜在用途。深入研究 RNA 和 RNA 结合蛋白之间的相互作用揭示了基因表达和调控的动态过程，为推进疾病机制的解析、药物的研究和发现提供了有价值的见解，促进了分子生物学的发展。
