Center for Prevention and Management of Overweight and Obesity, Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
Division of Endocrinology, Metabolism and Diabetes, ENDO-ERN Center for Rare Pediatric Endocrine Disorders, First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece.
Int J Mol Sci. 2024 Oct 22;25(21):11344. doi: 10.3390/ijms252111344.
Endocrine-disrupting chemicals (EDCs) are environmental and industrial agents that interfere with hormonal functions. EDC exposure is linked to various endocrine diseases, especially in reproduction, although the mechanisms remain unclear and effects vary among individuals. Neuroinflammation, particularly hypothalamic inflammation, is an emerging research area with implications for endocrine-related diseases like obesity. The hypothalamus plays a crucial role in regulating reproduction, and its inflammation can adversely affect reproductive health. EDCs can cross the blood-brain barrier, potentially causing hypothalamic inflammation and disrupting the reproductive axis. This review examines the existing literature on EDC-mediated hypothalamic inflammation. Our findings suggest that exposure to 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD), polychlorinated biphenyl (PCB), tributyltin (TBT), phthalates, bisphenol A (BPA), and chlorpyrifos (CPF) in animals is linked to hypothalamic inflammation, specifically affecting the hypothalamic centers of the gonadotropic axis. To our knowledge, this is the first comprehensive review on this topic, indicating hypothalamic inflammation as a possible mediator between EDC exposure and reproductive dysfunction. Further human studies are needed to develop effective prevention and treatment strategies against EDC exposure.
内分泌干扰化学物质（EDCs）是环境和工业制剂，它们会干扰激素功能。EDC 暴露与各种内分泌疾病有关，尤其是在生殖方面，尽管其机制尚不清楚，而且个体之间的影响也不同。神经炎症，特别是下丘脑炎症，是一个新兴的研究领域，对肥胖等与内分泌相关的疾病有影响。下丘脑在调节生殖方面起着至关重要的作用，其炎症可能会对生殖健康产生不利影响。EDCs 可以穿过血脑屏障，可能导致下丘脑炎症并破坏生殖轴。本综述考察了关于 EDC 介导的下丘脑炎症的现有文献。我们的研究结果表明，动物暴露于 2,3,7,8-四氯二苯并对二恶英（TCDD）、多氯联苯（PCB）、三丁基锡（TBT）、邻苯二甲酸酯、双酚 A（BPA）和毒死蜱（CPF）与下丘脑炎症有关，特别是影响生殖激素轴的下丘脑中枢。据我们所知，这是关于该主题的第一篇综合综述，表明下丘脑炎症可能是 EDC 暴露与生殖功能障碍之间的一个潜在介导因素。需要进一步的人类研究来制定针对 EDC 暴露的有效预防和治疗策略。
