Department of Experimental and Clinical Biomedical Sciences "Mario Serio", University of Firenze, 50134 Firenze, Italy.
Department of Medical, Surgery and Health Sciences, University of Trieste, 34100 Trieste, Italy.
Int J Mol Sci. 2024 Oct 25;25(21):11457. doi: 10.3390/ijms252111457.
Reactive oxygen species (ROS) contribute to endothelial dysfunction, platelet activation, and coagulation abnormalities, promoting thrombus formation. Given the growing interest in non-pharmacological approaches to modulate oxidative stress, we examine the potential of various dietary interventions and antioxidant supplementation in reducing oxidative damage and preventing thrombotic events. Key dietary patterns, such as the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), and ketogenic diets, as well as antioxidant-rich supplements like curcumin, selenium, and polyphenols, demonstrate promising effects in improving oxidative stress markers, lipid profiles, and inflammatory responses. This review highlights recent advances in the field, drawing from in vitro, ex vivo, and clinical studies, and underscores the importance of integrating dietary strategies into preventive and therapeutic approaches for managing thrombosis and cardiovascular health. Further research is needed to better understand long-term effects and personalize these interventions for optimizing patient outcomes.
活性氧（ROS）导致内皮功能障碍、血小板激活和凝血异常，从而促进血栓形成。鉴于人们对调节氧化应激的非药物方法越来越感兴趣，我们研究了各种饮食干预和抗氧化补充剂在减少氧化损伤和预防血栓事件方面的潜力。关键的饮食模式，如地中海饮食、停止高血压的饮食方法（DASH）和生酮饮食，以及富含抗氧化剂的补充剂，如姜黄素、硒和多酚，在改善氧化应激标志物、脂质谱和炎症反应方面显示出有希望的效果。本综述从体外、离体和临床研究中汲取了最新进展，强调了将饮食策略纳入预防和治疗血栓和心血管健康的重要性。需要进一步的研究来更好地了解长期效果并为患者的最佳治疗效果制定个性化的干预措施。
