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神经降压素及其在女性激素敏感性癌症中的作用。

Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers.

机构信息

Department of Gynecology and Obstetrics, CHRU de Nancy, Université de Lorraine, F-54000 Nancy, France.

Department of Fertility Medicine, CHRU de Nancy, Université de Lorraine, F-54000 Nancy, France.

出版信息

Int J Mol Sci. 2024 Oct 30;25(21):11648. doi: 10.3390/ijms252111648.

DOI:10.3390/ijms252111648
PMID:39519199
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11546766/
Abstract

Neurotensin (NT) is a peptide involved in digestion, neuromodulation, and cancer progression. NT and its receptors (NTR1 and SORT1 mainly) have been widely studied in oncology. Data show that NT expression is under the control of sex steroid hormones, in particular estradiol. We focused on its involvement in three main female hormone-sensitive cancers, breast, ovarian, and endometrial cancer, in a narrative review. NT, NTR1, and SORT1 are mostly expressed in these three cancers, and their involvement in oncologic processes such as proliferation and invasion seems to match, as does their impact on prognosis for most. The development of NT receptor-targeted therapies, including theranostics and radioligand treatments, presents a promising avenue for personalized cancer treatment.

摘要

神经降压素（NT）是一种参与消化、神经调节和癌症进展的肽。NT 及其受体（主要是 NTR1 和 SORT1）在肿瘤学中得到了广泛研究。数据表明，NT 的表达受性激素的控制，特别是雌二醇。我们在一篇叙述性综述中重点研究了它在三种主要的女性激素敏感型癌症（乳腺癌、卵巢癌和子宫内膜癌）中的作用。NT、NTR1 和 SORT1 在这三种癌症中表达较多，它们在增殖和侵袭等肿瘤发生过程中的作用似乎一致，对大多数癌症的预后影响也一致。开发针对 NT 受体的治疗方法，包括治疗学和放射性配体治疗，为癌症的个体化治疗提供了一个很有前途的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccef/11546766/f368ad3f90b8/ijms-25-11648-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccef/11546766/f368ad3f90b8/ijms-25-11648-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccef/11546766/f368ad3f90b8/ijms-25-11648-g001.jpg

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