Unidad de Investigación en Reproducción Humana, Instituto Nacional de Perinatología-Facultad de Química, Universidad Nacional Autónoma de México, Mexico City 11000, Mexico.
Department of Reproductive and Perinatal Health Research, Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Mexico City 11000, Mexico.
Int J Mol Sci. 2024 Oct 30;25(21):11655. doi: 10.3390/ijms252111655.
Pregnancy is distinguished by a multitude of intricate interactions between the mother and the new individual, commencing at implantation and persisting until the maturation and integration of the fetal apparatus and systems. The physiological increase in fat mass during pregnancy and the association of maternal obesity with adverse neonatal outcomes have directed attention to the study of maternal adipokines as participants in fetal development. Interestingly, maternal concentrations of certain adipokines such as adiponectin, leptin, tumor necrosis factor-alpha, and interleukin-6 have been found to be associated with offspring anthropometry and adiposity at birth and at three months of age, even with neurodevelopmental alterations later in life. This is partly explained by the functions of these adipokines in the regulation of maternal metabolism and placental nutrient transport. This review compiles, organizes, and analyzes the most relevant studies on the association between maternal adipokines with anthropometry, adiposity, and neurodevelopmental outcomes of the offspring. Furthermore, it proposes the underlying mechanisms involved in this association.
妊娠是母体与新个体之间一系列复杂相互作用的结果，始于着床并持续至胎儿器官和系统的成熟和整合。妊娠期间体脂量的生理性增加以及母体肥胖与不良新生儿结局的关联，促使人们关注作为胎儿发育参与者的母源脂肪因子。有趣的是，某些脂肪因子如脂联素、瘦素、肿瘤坏死因子-α和白细胞介素-6 的母体浓度与后代出生时和三个月时的人体测量学和肥胖程度有关，甚至与以后的神经发育改变有关。这部分可以用这些脂肪因子在调节母体代谢和胎盘营养转运方面的功能来解释。本综述综合、组织和分析了关于母源脂肪因子与后代人体测量学、肥胖程度和神经发育结局之间关联的最相关研究，并提出了这种关联所涉及的潜在机制。
